摘要
表观遗传学异常与肿瘤的关系一直备受关注。近年研究显示,翻译后修饰在肿瘤发生和发展过程中起重要作用。组蛋白去乙酰化酶(HDACs)可在转录和翻译后水平调节细胞内稳态。该文综述了结直肠癌中HDACs在翻译后修饰水平的致癌机制及HDACs抑制剂的应用前景。
The relationship between epigenetic abnormity and tumors has gained great attention.Recent studies demonstrate the crucial role of post-translational modifications during tumor development and progression.Histone deacetylases(HDACs)regulate intracellular homeostasis at transcription and posttranslation levels.This article reviews the carcinogenic mechanisms of HDACs at post-translational modification level and application prospect of HDACs inhibitors in colorectal cancer.
作者
何佩珊
龙嘉莉
何清莲
殷玉婷
廖燕秋
雷雪
李紫琪
朱伟
HE Pei-shan;LONG Jia-li;HE Qing-lian;YIN Yu-ting;LIAO Yan-qiu;LEI Xue;LI Zi-qi;ZHU Wei(Guangdong Medical University,Dongguan 523808,China)
出处
《广东医科大学学报》
2019年第5期521-525,共5页
Journal of Guangdong Medical University
基金
国家自然科学基金(No.81472275)
广东省自然科学基金(No.2014A030313542)
关键词
组蛋白去乙酰化酶
结直肠癌
翻译后修饰
histone deacetylase
colorectal cancer
post-translational modification
