摘要
动物实验在医学领域的研究中不可或缺,众多学者致力于使动物实验数据结果更加准确、可靠、科学,与人体反应更加接近。大多数人类疾病及并发症往往具有年龄相关性,药物研究也需与年龄匹配,且机体发育和衰老的不同阶段对药物的反应也不尽相同。因此,良好的动物实验必须在尽可能与人类年龄相似的生命阶段中开展。多年来国内外学者们针对动物与人类发育比对及年龄相关性进行了大量研究,本研究旨在总结常用实验动物(大小鼠、兔)与人类发育,年龄匹配相关理论和研究方法,即物种之间的相似性在特定发展阶段反映出基本相似的生物过程的程度,为动物实验提供参考。
Animal research,which plays a critical role in drug discovery,has been of central importance for the production of background knowledge for clinical investigations and the optimization of procedures prior to human trials. An important feature of in vivo modeling is matching of the age of animals used in preclinical research to the age of peak incidence for a disease state in humans. Indeed,it is clear that animal models must match humans at a similar stage of life to be used as successful platforms for clinical translation,as many conditions that are targeted for drug treatment are age dependent. Valid age matching is critical for successful use of animal modelling in biomedical research in general and,in particular,drug discovery. It is important for researchers to understand that relative ages are different depending upon the stage of life. Therefore,one has to determine the relevant age under investigation and what factors are being analyzed. For this,special attention is needed to verify the phase of life of the animal( in days) and its correlation with the age of humans( in years). In this article,we focus on an even more specific issue: the degree to which similarities between species reflect fundamentally similar biological processes at a particular stage of development or age.
作者
陈玥
苏丹
贵文娟
孙效容
CHEN Yue;SU Dan;GUI Wenjuan;SUN Xiaorong(Chengdu Bio-HT Company Limited,Chengdu 610000,China;General Hospital of Ningxia Medical University,Yinchuan 750004)
出处
《中国比较医学杂志》
CAS
北大核心
2019年第11期116-122,共7页
Chinese Journal of Comparative Medicine
关键词
实验动物
生物学年龄
发育
人类年龄
laboratory animal
biological age
developmental biology
human lifespan
