摘要
炎症性肠病(IBD)包括溃疡性结肠炎(UC)和克罗恩病(CD)。越来越多的证据表明,艾灸能明显改善溃疡性结肠炎和克罗恩病的症状,减轻炎症反应,目前其作用机制尚不明确。艾灸对炎症性肠病的调控机制主要参与机体免疫反应相关,而其抗炎的作用机制可能受表观遗传学的调控,参与促炎细胞因子和抑炎细胞因子的调控。该综述了艾灸治疗炎症性肠病的表观遗传修饰相关作用机制,并且从表观遗传学角度为艾灸诊断和治疗炎症性肠病提供新的思路和途径。
Inflammatory bowel disease(IBD)includes ulcerative colitis(UC)and Crohn’s disease(CD).More and more evidences show that moxibustion can significantly improve the symptoms of ulcerative colitis and Crohn’s disease,and reduce the inflammatory reaction.At present,the mechanism of moxibustion is still unclear.The regulation mechanism of moxibustion on inflammatory bowel disease is mainly related to the immune response,and its anti-inflammatory mechanism may be regulated by epigenetic modification,participating in the regulation of anti-inflammatory cytokines and pro-inflammatory cytokines,so as to transform the body from chronic inflammatory state to immune protection and tolerance.This paper reviews the mechanism of epigenetic modification of moxibustion on inflammatory bowel disease,and provides new ideas and approaches for moxibustion diagnosis and treatment of inflammatory bowel disease from the perspective of epigenetics.
作者
罗娇娇
金晶
王梦雪
康增平
赵海梅
刘端勇
王海燕
LUO Jiao-jiao;JIN Jing;WAN Meng-xue;KANG Zeng-ping;ZHAO Hai-mei;LIU Duan-yong;WANG Hai-yan(Jiangxi University of Chinese Medicine,Nanchang Jiangxi 330004,China)
出处
《时珍国医国药》
CSCD
北大核心
2021年第5期1198-1200,共3页
Lishizhen Medicine and Materia Medica Research
基金
国家自然科学基金项目(81803988,81760838,81460679)
江西省卫生计生委中医药科研课题(2015A246)
江西省自然科学基金(20181BAB205082,20171BAB205088)
江西省教育厅科技项目(GJJ151564)。
关键词
艾灸
炎症性肠病
溃疡性结肠炎
克罗恩病
DNA甲基化
Moxibustion
Inflammatory bowel disease
Ulcerative colitis
Crohn’s disease
DNA methylation
