摘要
本文探讨了桑叶水提物降脂减肥作用及其对脂肪代谢关键酶活性的影响,以初步揭示其降脂作用机理。对高脂饮食小鼠同时灌胃桑叶水提物,于8,12,16周采集小鼠血液和肝脏,用试剂盒测定血脂水平和肝脏中脂肪代谢关键酶的活性。结果发现,高脂饮食雄鼠在灌胃高剂量桑叶水提物12周后,血脂水平基本恢复正常,与HFC组相比,其体质量增加率降低22.52%,腹腔脂肪系数降低32.67%,血清TC含量降低41.29%,TG含量降低36.60%,LDL-C含量降低31.28%,HDL-C含量增加47.20%;肝脏中FAS活性降低23.99%,LPL活性上升21.22%,HL活性上升32.91%。高脂饮食雌鼠灌胃高剂量桑叶水提物8周后,血脂水平基本恢复正常,与HFC组相比,其体质量增加率降低26.58%,腹腔脂肪系数降低40.74%,血清中TC含量降低42.53%,TG含量降低41.75%,LDL-C含量降低29.33%,HDL-C含量增加22.46%;肝脏中FAS活性降低22.49%,HSL活性上升31.98%。可见,灌胃适量桑叶水提物一定时间能够抑制脂肪合成,加速脂肪动员,从而减少脂肪沉积,达到降脂减肥,缓解高脂血症的目的。
This study explored the effect of water extract of mulberry leaf on lipid metabolism,to illuminate its’lipid-lowering mechanism.Giving high-fat mice different dosage mulberry leaf water extract for 8,12 and 16 weeks,then collected their blood and livers to determine the level of blood lipid and the activity of enzymes by kits.Male mice were given high dosage mulberry leaf water extract for 12 weeks,its level of blood lipid returned to normal.Compared with HFC group,the rate of weight-gain were decreased by 22.52%,abdominal fat factors were decreased by 32.67%,contents of TC,TG,LDL-C in serum were decreased by 41.29%,36.60%and 31.28%respectively,contents of HDL in serum were increased by 47.20%,activity of FAS in liver were decreased by 23.99%,activity of LPL,HL in liver were increased by 21.22%and 32.91%.Female mice were given high dosage mulberry leaf water extract for 8 weeks,its level of blood lipid returned to normal.Compared with HFC group,the rate of weight-gain were decreased by 26.58%,abdominal fat factors were decreased by 40.74%,contents of TC,TG,LDL-C in serum were decreased by 42.53%,41.75%and 29.33%respectively,contents of HDL in serum were increased by 22.46%,activity of FAS in liver were decreased by 22.49%,activity of HSL in liver were increased by 31.98%.Giving high-fat mice mulberry leaf water extract for a certain period,which can inhibit fat synthesis and accelerate fat decompose,to reduce fat accumulation and improve the level of blood lipid.
作者
王玲
邹莉芳
黄先智
丁晓雯
Wang Ling;Zou Lifang;Huang Xianzhi;Ding Xiaowen(College of Food Science,Southwest University,Chongqing 400716;State Key Laboratory of Silkworm Genome Biology,Chongqing 400716)
出处
《中国食品学报》
EI
CAS
CSCD
北大核心
2019年第10期23-33,共11页
Journal of Chinese Institute Of Food Science and Technology
基金
公益性行业(农业)科研专项(201403049,201303053)
现代农业产业技术体系建设专项(CARS-22)
关键词
桑叶水提物
高脂饮食
脂代谢
酶活
mulberry leaf water extract
high-fat fed
lipid metabolism
activity of enzyme
