摘要
目的:探讨加味柴芩承气汤治疗腑实热结型急性胰腺炎的效果及对CRP、TNF-α、IL-6的影响。方法:选取2017年8月-2019年6月在本院确诊为腑实热结型急性胰腺炎的患者86例,随机均分为观察组和对照组,各43例。对照组给予常规西医治疗,观察组在对照组基础上给予加味柴芩承气汤治疗。比较两组治疗前后血清炎症因子水平变化、治疗后临床症状体征恢复正常所需时间及治疗效果。结果:治疗前两组CRP、TNF-α、IL-6水平比较,差异均无统计学意义(P>0.05);治疗后观察组CRP、TNF-α、IL-6水平均明显低于对照组(P<0.05)。观察组上腹压痛、腹胀、肛门排气、AMS及WBC计数恢复正常时间均明显短于对照组,观察组总有效率为95.35%明显高于对照组的81.40%,差异均有统计学意义(P<0.05)。结论:腑实热结型急性胰腺炎患者在常规治疗的基础上给予加味柴芩承气汤治疗,可降低CRP、TNF-α、IL-6水平,缩短症状体征恢复正常所需时间,取得显著的临床治疗效果。
Objective:To investigate the effect of Jiawei Chaiqin Chengqi Decoction in the treatment of phlegm-heat type acute pancreatitis and its effect of CRP,TNF-α and IL-6.Method:Eighty-six patients with phlegm-heat type acute pancreatitis diagnosed in our hospital from August 2017 to June 2019 were randomly divided into the observation group and the control group,43 cases in each group.The control group was treated with conventional western medicine,and the observation group was treated with Jiawei Chaiqin Chengqi Decoction on the basis of the control group.The changes of serum inflammatory factors levels before and after treatment,the time required for clinical symptoms and signs to return to normal after treatment,and the treatment effects of two groups were compared.Result:There were no significant differences in CRP,TNF-α and IL-6 levels between two groups before treatment(P>0.05).The levels of CRP,TNF-α and IL-6 in the observation group were significantly lower than those in the control group after treatment(P<0.05).The time to return to normal upper abdomen tenderness,abdominal distension,anal exhaust,AMS and WBC counts in the observation group were significantly shorter than those of the control group,the total effective rate of the observation group was 95.35%,which was significantly higher than 81.40% of the control group(P<0.05).Conclusion:The treatment of patients with phlegm-heat type acute pancreatitis treated with Jiawei Chaiqin Chengqi Decoction can reduce the levels of CRP,TNF-α and IL-6 and shorten the time required for patients to recover from symptoms and signs,the clinical effect is remarkable.
作者
张乃
章永南
曾鹏
龚韬
陶璐
张静智
ZHANG Nai;ZHANG Yongnan;ZENG Peng(Jiangxi Provincial Hospital of Integrated Traditional Chinese and Western Medicine,Nanchang 330003,China)
出处
《中国医学创新》
CAS
2019年第27期73-76,共4页
Medical Innovation of China
基金
赣州市指导性科技计划项目（GZ2018ZSF262）
