摘要
目的:分析黄体酮联合孕康口服液用于习惯性流产的疗效及对转化生长因子-β1(TGF-β1)、子宫内膜抗体(EmAb)、孕激素诱导阻断因子(PIBF)、抗心磷脂抗体(ACA)的影响。方法:86例习惯性流产患者来自于我院2013年12月至2016年12月,按照随机数字法分为对照组和实验组,每组43例。对照组选用黄体酮治疗,实验组基于对照组加以孕康口服液治疗。观察并比较两组疗效,临床症状积分,TGF-β1,EmAb,PIBF,ACA,及不良反应发生情况。结果:实验组总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后1周及2周,两组临床症状积分,血清EmAb,ACA水平均较治疗前显著下降,实验组上述指标低于对照组,两组血清TGF-β1,PIBF水平均较治疗前明显上升,实验组上述指标高于对照组,两组临床症状积分、TGF-β1、EmAb、PIBF、ACA在不同治疗方法、治疗时间上的差异有统计学意义(P<0.05)。两组不良反应比较差异无统计学意义(P>0.05)。结论:黄体酮联合孕康口服液用于习惯性流产的疗效优于黄体酮,能够促进TGF-β1、PIBF表达,降低EmAb、ACA水平,发挥保胎作用。
Objective:To analyze the effect of progesterone combined with Yunkang oral liquid on habitual abortion and its effects on transforming growth factor-beta 1(TGF-beta 1),endometrial antibody(EmAb),progesterone-induced blocking factor(PIBF)and anticardiolipin antibody(ACA).Methods:86 cases of habitual abortion patients from December 2013 to December 2016 in our hospital were divided into control group and experimental group according to random number method,43 cases in each group.The control group was treated with progesterone,and the experimental group was treated with Yunkang oral liquid based on the control group.The curative effect,clinical symptom score,TGF-beta 1,EmAb,PIBF,ACA and adverse reactions were observed and compared between the two groups.Results:Total effective rate of experimental group was higher than the control group,the difference was statistically significant(P<0.05).One week and two weeks after treatment,the scores of clinical symptoms,serum EmAb and ACA levels in the two groups were significantly lower than those before treatment.The above indexes in the experimental group were lower than those in the control group.The levels of serum TGF-beta 1 and PIBF in the two groups were significantly higher than those before treatment.The above indexes in the experimental group were higher than those in the control group.The scores of clinical symptoms,TGF-beta 1,EmAb,PIBF and ACA were in the two groups.There were significant differences in different treatment methods and treatment time(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion:Progesterone combined with Yunkang oral liquid is better than progesterone in the treatment of habitual abortion.It can promote the expression of TGF-beta 1 and PIBF,reduce the levels of EmAb and ACA,and play a role in fetal protection.
作者
郑敏
于峰
肖瑶
ZHENG Min;YU Feng(Rizhao City Maternal and Child Health Hospital,Shandong Rizhao 276800,China)
出处
《河北医学》
CAS
2019年第9期1434-1438,共5页
Hebei Medicine
基金
山东省科技发展计划,(编号:2014GGH218026)
关键词
习惯性流产
孕康口服液
黄体酮
转化生长因子-β1
子宫内膜抗体
孕激素诱导阻断因子
抗心磷脂抗体
Habitual abortion
Yunkang oral solution
Progesterone
Transforming growth factor-β1
Endometrial antibody
Progesterone induced blocking factor
Anti cardiolipin antibody