摘要
目的:观察主动免疫疗法、黄体酮注射液、孕康口服液三联治疗习惯性流产患者的效果。方法:选取92例习惯性流产患者为研究对象,按照随机数字表法分为观察组与对照组各46例。对照组予以黄体酮注射液联合孕康口服液治疗,观察组在对照组基础上增加主动免疫疗法治疗,比较两组疗效及转化生长因子-β;(TGF-β;)、抗子宫内膜抗体(EMAb)、孕激素诱导阻断因子(PIBF)和抗心磷脂抗体(ACA)水平。结果:观察组治疗总有效率为91.30%,明显高于对照组的45.65%,差异有统计学意义(P<0.05);治疗12周后,两组TGF-β;水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);治疗12周后,两组EMAb OD值均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗12周后,两组PIBF水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);治疗12周后,两组ACA水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。结论:主动免疫疗法、黄体酮注射液、孕康口服液三联治疗习惯性流产患者可提高治疗总有效率、TGF-β;水平和PIBF水平,降低EMAb OD值和ACA水平,效果优于黄体酮注射液联合孕康口服液治疗。
Objective: To observe effect of triple therapy of active immunotherapy, Progesterone injection, and Yunkang oral liquid in treatment of patients with habitual abortion. Methods: 92 patients with habitual abortion were selected as the research objects and were divided into observation group and control group according to the random number table method, 46 cases in each group. The control group was treated with Progesterone injection combined with Yunkang oral liquid, while the observation group was treated with active immunotherapy on the basis of those of the control group. The curative effects, the transforming growth factor β;(TGF-β;) level, the anti-endometrial antibody(EMAb) level, the progesterone-induced blocking factor(PIBF) level and the anticardiolipin antibody(ACA) level were compared between the two groups. Results:The effective rate of the observation group was 91.30%, which was significantly higher than the control group of 45.65%, and the difference was statistically significant(P<0.05). After 12 weeks of treatment, the levels of TGF-β;in the two groups were higher than before the treatment;that of observation group was higher than that of control group;and the difference was statistically significant(P<0.05). After 12 weeks of treatment, the OD values of EMAb in the two groups were lower than those before the treatment;those of the observation group were lower than those of the control group;and the differences were statistically significant(P<0.05). After 12 weeks of treatment, the levels of PIBF in the two groups were higher than before the treatment;that of the observation group was higher than that of the control group;and the difference was statistically significant(P<0.05).Further, after 12 weeks of treatment, the ACA levels in the two groups were lower than before the treatment;that of the observation group was lower than that of the control group;the difference was statistically significant(P<0.05). Conclusions: The triple therapy of active immunotherapy, progesterone injection, and Yunk
作者
王晓晓
WANG Xiaoxiao(Department of Obstetrics of the First People’s Hospital of Ruzhou,Ruzhou 467500 Henan,China)
出处
《中国民康医学》
2022年第8期52-54,共3页
Medical Journal of Chinese People’s Health
