摘要
目的探讨烯丙雌醇在治疗先兆流产中的应用价值。方法选择2018年6月至2019年12月在本院诊治的符合研究条件的先兆流产80例患者作为研究对象,按照随机数字表法分成观察组和对照组,每组各40例。对照组根据孕周仅给予地屈孕酮或联合利托君治疗,观察组在对照组的基础上加用烯丙雌醇口服。比较两组之间的治疗效果(包括有效率、流产率、早产率、足月产率及终止妊娠时平均孕龄)。结果观察组治疗总有效率(90.00%)高于对照组(72.50%);足月产率(75.00%)高于对照组(52.50%),流产率(5.00%)低于对照组(20.00%),以上指标差异均有统计学意义(χ^(2)=4.021,4.114,4.381;P=0.045,0.043,0.036);观察组早产率(20.00%)与对照组(27.50%)相比无统计学差异(χ^(2)=0.621,P=0.431),但观察组早产平均孕龄[(235.90±19.57)d]高于对照组[(221.54±24.84)d],t=2.872,P=0.005。结论口服烯丙雌醇治疗先兆流产能够帮助患者改善临床症状,减少流产率,提高足月产率,延长早产儿孕龄。
Objective To study the clinical effect of allylestrenol in the treatment of threatened abortion.Methods Eighty patients with threatened abortion who met the research conditions in our hospital from June 2018 to December 2019 were selected as the research objects and randomly divided into the observation group and the control group with 40 cases in each group.The control group was given dydrogesterone or combined with ritodrine according to the gestational age,and the observation group was given allylestrenol orally on the basis of the control group.The therapeutic effects(including effective rate,abortion rate,premature birth rate,full-term rate and average gestational age at termination of pregnancy)were compared between the two groups.Results The total effective rate of the observation group(90.00%)was higher than that of the control group(72.50%),the full-term rate(75.00%)was higher than that of the control group(52.50%),and the abortion rate(5.00%)was lower than that of the control group(20.00%).The differences of the above indexes were statistically significant(χ^(2)=4.021,4.114,4.381,P=0.045,0.043,0.036).The preterm birth rate of the observation group(20.00%)was not significantly different from that of the control group(27.50%)(χ^(2)=0.621,P=0.431),but the average gestational age of the observation group[(235.90±19.57)days]was higher than that of the control group[(221.54±24.84)days](t=2.872,P=0.005).Conclusion Oral allylestrenol can help patients improve clinical symptoms,reduce abortion rate,improve full-term rate and prolong the gestational age of premature infants.
作者
尤海英
刘银春
张瑞珍
张晓萍
YOU Haiying;LIU Yinchun;ZHANG Ruizhen;ZHANG Xiaoping(Qingyuan Maternal and Child Health Hospital,Qingyuan 511500,China)
出处
《中国医药指南》
2021年第18期22-24,共3页
Guide of China Medicine
关键词
先兆流产
烯丙雌醇
地屈孕酮
利托君
Threatened abortion
Allylestrenol
Dydrogesterone
Ritodrine
