摘要
N^6-甲基腺嘌呤(N^6-methyladenosine,m6A)作为一种重要的表观遗传修饰方式,在干细胞命运决定、精子形成、肌肉发育、脂肪沉积及人类肿瘤发生中发挥重要作用。m^6A修饰最重要的作用是调控基因表达,它是细胞中基因表达调控的表观遗传学机制之一。文章综述了m^6A调控基因表达的分子机制及m^6A介导的生物学功能的研究进展,探讨了m^6A RNA甲基化的研究趋势和未来发展方向。
N^6-methyladenosine(m^6 A) RNA modification is an important epigenetic modifcation and plays crucial roles in stem cell fate determination, spermatogenesis, muscle development, fat deposition and human tumorigenesis. The key role of m^6A methylation is the regulation of gene expression, and m^6A methylation is one of several epigenetic mechanisms that cells use to regulate gene expression. This review focuses on recent advances of the mechanisms of m^6A regulating gene expression and biological function mediated by m^6A, and discusses the ongoing trends and future research directions of m^6A RNA methylation.
作者
刘畅
陈洪艳
张琦
张心扬
李辉
程博涵
LIU Chang;CHEN Hongyan;ZHANG Qi;ZHANG Xinyang;LI Hui;CHENG Bohan(Key Laboratory of Chicken Genetics and Breeding,Ministry of Agriculture and Rural Affairs,Harbin,Heilongjiang 150030;Key Laboratory of Animal Genetics,Breeding and Reproduction,Education Department of Heilongjiang Province,Harbin,Heilongjiang 150030;College of Animal Science and Technology,Northeast Agricultural University,Harbin,Heilongjiang 150030)
出处
《中国家禽》
北大核心
2019年第14期50-54,共5页
China Poultry
基金
国家高技术研究发展计划(863计划)项目(2013AA102501)
现代农业产业技术体系建设专项资金(CARS-41)
黑龙江省高校青年创新人才培养资金项目(UNPYSCT-2018145)
