摘要
在真核生物、原核生物及病毒的基因组中存在着调控基因表达的顺式元件,沉默子是其中的一种负调控元件,它能够同反式因子协同作用,抑制靶基因的转录活性,在基因表达调控中发挥重要作用。该文主要对沉默子的特性、结构组成及其分类进行简要总结,对沉默子可能作用机制进行简要综述,最后展望沉默子在遗传工程及人类疾病治疗等领域的应用前景。
Cis-elements regulating gene expression exist in eukaryotes, prokaryotes and viral genomes. Silencer is one of the negative regulatory elements, which can synergistically act with trans-factors to inhibit the transcriptional activity of target genes and play an important role in gene expression regulation. In this paper, the characteristics,structure and classification of silencer are briefly summarized. The possible mechanism by which silencer inhibits gene expression is briefly reviewed. Finally, the application prospect of silencer in the field of genetic engineering and human disease treatment is prospected.
作者
胡朝阳
唐培培
邓炎春
孙伟娟
姚勤
HU Zhao-Yang;TANG Pei-Pei;DENG Yan-Chun;SUN Wei-Juan;YAO Qin(Institute of Life Sciences,Jiangsu University,Zhenjiang 212013,China)
出处
《生命科学》
CSCD
北大核心
2019年第7期686-692,共7页
Chinese Bulletin of Life Sciences
基金
国家自然科学基金项目(31570150)
关键词
顺式元件
沉默子
负调控元件
基因表达调控
cis-elements
silencer
negative regulatory elements
regulation of gene expression
