摘要
N6-甲基腺苷(m6A)修饰是真核生物mRNA中最常见的甲基化修饰形式,在mRNA剪接、降解和翻译等过程中发挥着重要的作用.m6A修饰可通过调节RNA转录后加工过程影响细胞和生物体的正常生命活动,这其中包括生物的性别决定过程.已有研究结果表明:m6A甲基转移酶(Writers)和m6A结合蛋白(Readers)组分通过调控Sxl mRNA的可变剪接,进而参与黑腹果蝇性别决定过程,缺乏Writers和Readers组分会使雌性黑腹果蝇出现雄性特征;m6A修饰对鸡和比目鱼的性腺发育和性别分化均有影响,这也表明m6A修饰对性别决定的调控在自然界具有一定的普遍性,因此,进一步探究m6A修饰在生物性别决定过程中的分子调控机制具有十分重要的意义.
N6-methyladenosine(m6A)modification is the most abundant form of methylation modification in eukaryotic mRNA and plays an important role in mRNA splicing,degradation,and translation.m6A modification can affect the normal activities of cells and organisms,including sex determination.Previous works suggest that components of m6A methyltransferase(Writers)and m6A binding protein(Readers)participate in sex determination in Drosophila by regulating alternative splicing of Sxl mRNA;the absence of Writers and Readers component causes male characteristics on female Drosophila.m6A modification is found to affect gonad development and sex differentiation in chicken and flounder;this suggests that m6A modification regulation of sex determination are universal in nature.Further works may be needed to explore regulatory mechanism of m6A modification in sex determination.
作者
刘心雨
孙林
LIU Xinyu;SUN Lin(College of Life Sciences,Beijing Normal University,Beijing Key Laboratory of Gene Resource and Molecular Development,Beijing Normal University,100875,Beijing,China;Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education,Beijing Normal University,100875,Beijing,China)
出处
《北京师范大学学报（自然科学版）》
CAS
CSCD
北大核心
2023年第4期558-563,共6页
Journal of Beijing Normal University(Natural Science)
基金
国家自然科学基金资助项目(32070566,31871243)。
关键词
表观遗传学
m6A修饰
性别决定
黑腹果蝇
epigenetics
m6A modification
sex determination
Drosophila melanogaster
