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抗环瓜氨酸肽抗体、类风湿因子及超敏C反应蛋白鉴别诊断类风湿关节炎与骨关节炎的临床价值 被引量:6

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摘要 目的探讨抗环瓜氨酸肽(CCP)抗体、类风湿因子(RF)及超敏C反应蛋白(hs-CRP)鉴别诊断类风湿关节炎与骨关节炎的临床价值。方法选择2018年3月至2019年1月收治的类风湿关节炎患者47例作为RA组,另选取同期收治的骨关节炎患者31例作为OA组,分别对两组进行血清学检测。比较两组抗CCP抗体、RF及hs-CRP水平,并分析抗CCP抗体、RF及hs-CRP单一诊断和联合诊断类风湿关节炎的灵敏度、特异度。结果与OA组相比,RA组抗CCP抗体、RF、hs-CRP高,差异均有统计学意义(P<0.05);RA组抗CCP抗体、RF、hs-CRP、抗CCP抗体+RF、RF+hs-CRP及hs-CRP+抗CCP抗体阳性检出率均高于OA组,差异均有统计学意义(P<0.05);抗CCP抗体(93.50%)及RF(96.80%)的诊断灵敏度最高;联合检测中抗CCP抗体+RF检测灵敏度最高。结论抗CCP抗体、RF及hs-CRP均可作为临床诊断类风湿关节炎和骨关节炎的重要参考指标,而抗CCP抗体+RF联合检测,可提高临床检测灵敏度。
出处 《医疗装备》 2019年第14期43-44,共2页 Medical Equipment
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