摘要
目的分析中性粒细胞/淋巴细胞比率(neutrophil/lymphocyte ratio,NLR)、心型脂肪酸结合蛋白(heart-type fatty acid binding protein,H-FABP)、脑钠肽(brain natriuretic peptide,BNP)在急性肺栓塞(acute pulmonary embolism,APE)中的表达意义。方法选取2016年1月至2017年6月襄阳市中心医院收治的142例疑似肺栓塞患者作为研究对象,通过影像学检查将APE患者(94例)纳入研究组,非APE患者(48例)纳入对照组,根据临床症状将研究组患者分为大面积肺栓塞组(24例)、次大面积肺栓塞组(39例)和非大面积肺栓塞组(31例)。分别检测各组患者NLR、血清H-FABP和BNP水平,受试者操作特征曲线评价NLR、血清H-FABP和BNP水平在APE诊断中的价值。结果研究组患者NLR、血清H-FABP和BNP水平均显著高于对照组(均P < 0.05);大面积肺栓塞组患者NLR、血清H-FABP和BNP水平均显著高于次大面积肺栓塞组和非大面积肺栓塞组(均P < 0.05),患者NLR、血清H-FABP和BNP水平随肺栓塞面积增大呈显著上升趋势。NLR、血清H-FABP和BNP水平诊断APE的临界值分别为7.81、7.06、130.61,特异性分别为100%、84.37%、91.67%,敏感性分别为72.34%、70.04%、81.91%。结论 NLR、血清H-FABP和BNP水平在APE患者中异常升高,与APE危险分层有关,具有早期诊断的重要价值。
Objective To analyze the expression of neutrophil/lymphocyte ratio(NLR), heart-type fatty acid binding protein(H-FABP) and brain natriuretic peptide(BNP) in acute pulmonary embolism(APE). Method 142 suspected pulmonary embolism patients admitted to Xiangyang Central Hospital from January 2016 to June 2017 were selected as the research subjects. 94 patients with APE were included in study group and 48 patients with non-APE were included in control group by imaging examination. According to the clinical symptoms, study group patients were divided into large area pulmonary embolism group(24 cases), sub-large area pulmonary embolism group(39 cases) and non-large area pulmonary embolism group(31 cases). The levels of NLR, serum H-FABP and BNP were detected in each group, the receiver operator characteristic(ROC) curve was used to evaluate the value of NLR, serum H-FABP and BNP levels in the diagnosis of APE. Result The levels of NLR, serum H-FABP and BNP in study group were significantly higher than those in control group(all P < 0.05);the levels of NLR, serum H-FABP and BNP in large area pulmonary embolism group were significantly higher than those in sub-large area pulmonary embolism group and non-large area pulmonary embolism group(all P < 0.05), the levels of NLR, serum H-FABP and BNP increased significantly with the increased of pulmonary embolism area. The critical values of NPE, H-FABP and BNP for diagnosis of APE were 7.81, 7.06 and 130.61 respectively, the specificities were 100%, 84.37% and 91.67% respectively, and the sensitivity were 72.34%, 70.04% and 81.91% respectively. Conclusion NLR, H-FABP and BNP are abnormally elevated in APE patients, which are related to the risk stratification of APE, and have important value in early diagnosis.
作者
黄远东
宋宁
唐丹丹
HUANG Yuan-dong;SONG Ning;TANG Dan-dan(Department of Respiratory Medicine,Xiangyang Central Hospital,Affiliated Hospital of Hubei College of Arts and Sciences,Hubei Xiangyang 441021,China;Department of Respiratory Medicine,Shijiazhuang Central Hospital,Shijiazhuang 050011,China)
出处
《中国医学前沿杂志（电子版）》
2019年第9期69-72,共4页
Chinese Journal of the Frontiers of Medical Science(Electronic Version)
基金
河北省医学科学研究重点计划(20110583)
关键词
急性肺栓塞
中性粒细胞/淋巴细胞比率
心型脂肪酸结合蛋白
脑钠肽
Acute pulmonary embolism
Neutrophil/lymphocyte ratio
Heart-type fatty acid binding protein
Brain natriuretic peptide
