摘要
何首乌作为传统的中药材,临床应用极其普遍。随着何首乌肝毒性报道越来越多,其安全性日益受到重视。本文主要从临床案例、化学成分及毒性物质基础、毒性机制等方面对何首乌的肝毒性进行综述,为何首乌临床安全用药及肝毒性机制研究提供参考。
Polygonum multiflorum is a traditional Chinese medicine with commonly clinical application. With increasing cases of Polygonum multiflorum related hepatotoxicity reported, the drug safety problem has been received more and more attention. This article reviews the toxicity characteristics of Polygonum multiflorum from the aspects of clinical cases, chemical composition and toxic material basis, and hepatotoxicity mechanism. We aim to provide a useful reference for the clinical use and mechanism research of Polygonum multiflorum.
作者
于瑞丽
门伟婕
周昆
于英莉
YU Ruili;MEN Weijie;ZHOU Kun;YU Yingli(Institute of Traditional Chinese Medicine, TianJin University of Traditional Chinese Medicine, TianJin 301617, China;Institute of Traditional Chinese Medicine, Ministry of Education Key Laboratory of Traditional Chinese Medical Formulae, Tianjin University of TCM, TianJin 301617, China)
出处
《中国药物警戒》
2019年第8期496-503,共8页
Chinese Journal of Pharmacovigilance
基金
国家重大新药创制专项(2014ZX09304307-001-005、2015ZX09501004-003-004):中药新药安全性检测技术与标准研究、中药成药性优化技术研究
关键词
何首乌
肝毒性
肝损伤
毒性物质基础
Polygonum multiflorum
hepatotoxicity
liver injury
toxic material basis
