摘要
目的探讨首荟通便胶囊辅助治疗老年功能性便秘的临床疗效。方法选取淮安市第二人民医院消化内科2016年8月—2018年8月收治的老年功能性便秘患者98例,随机分为观察组和对照组,每组49例;二组患者治疗期间均注意饮食,以摄取膳食纤维为主,多饮水,保持一定的运动,避免长期卧床,对照组服用乳果糖口服液,15 ml/次,2次/d,连续治疗4周;观察组在对照组基础上加服首荟通便胶囊,2粒/次,3次/d,连续治疗4周。依据临床体征变化判断疗效,并对自主排便频率、排便困难程度及腹痛、腹胀、排便不尽感进行评分,统计患者停药后4周复发情况。结果临床疗效显示,对照组显效16例(32.7%),无效12例(24.5%),总有效率达到75.5%;观察组显效19例(38.7%),总有效率达到91.8%,远高于对照组,而无效仅4例(8.2%),远低于对照组,二组比较差异有统计学意义(t=3.722,P<0.05);临床症状评分显示,治疗后对照组自主排便频率降为(1.05±0.58)分,高于观察组的(0.66±0.35)分;对照组腹胀、腹痛、排便不尽感评分降为(1.37±0.89)分,高于观察组的(0.78±0.55)分;而排便困难程度评分显示,对照组排便比观察组困难;停药后4周统计复发情况显示,对照组有4例,复发率为8.2%;观察组1例,复发率仅为2.0%。结论首荟通便胶囊可以有效提高恶性肿瘤化疗后便秘的治疗效率,有效缓解患者排便疼痛程度,减少排便时间,效果显著,值得临床推广。
Objective To investigate the clinical effect of shouhui tongbian capsule in the treatment of senile functional constipation.Methods A total of 98 elderly patients with functional constipation admitted to the department of gastroenterology of the hospital from August 2016 to August 2018 were randomly divided into observation group and control group,with 49 cases in each group.During the treatment,both groups paid attention to diet,mainly taking dietary fiber,drinking more water,keeping certain exercise,and avoiding long-term bed rest.The control group took lactiflora oral liquid,15 ml each time,twice a day,for 4 weeks.The observation group was added to the control group with shouhui laxative capsule,2 capsules at a time,3 times a day,continuous treatment for 4 weeks.The curative effect was judged according to the changes of clinical signs,and the frequency of spontaneous defecation,difficulty degree of defecation,abdominal pain,abdominal distension and incomplete defecation were scored,and the recurrence of the patients at 4 weeks after drug withdrawal was counted.Results According to the clinical efficacy,16 cases(32.7%)were significantly effective in the control group,12 cases(24.5%)were ineffective,and the total effective rate reached 75.5%.The total effective rate reached 91.8%in the observation group(38.7%),which was much higher than that in the control group,and only 4 cases(8.2%)were ineffective,which was much lower than that in the control group.The difference between the two groups was statistically significant(t=3.722,P<0.05).The clinical symptom score showed that the frequency of spontaneous defecation in the control group decreased to(1.05±0.58)after treatment,which was higher than that in the observation group(0.66±0.35).The scores of abdominal distension,abdominal pain and defecation dissatisfaction in the control group decreased to(1.37±0.89),which was higher than that of the observation group(0.78±0.55).The score of difficulty in defecating showed that the control group had more difficulty in d
作者
周佳宝
周锦花
ZHOU Jiabao;ZHOU Jinhua(Department of Pharmacy,Huai'an Second People's Hospital,Huai'an 223300,China)
出处
《中国全科医学》
CAS
北大核心
2019年第S02期149-151,共3页
Chinese General Practice
关键词
首荟通便胶囊
老年功能性便秘
乳果糖
Shouhui tongbian capsule
Senile functional constipation
lactulose
