摘要
目的观察神经生长因子(nerve growth factor,NGF)及前列腺素F-2α受体(prostaglandin F2αreceptor,PTGFR)在子宫腺肌病(adenomyosis,AM)痛经患者宫颈组织中的表达情况。方法选取40例子宫腺肌病痛经行子宫全切术患者为试验组,选取同期无痛经行子宫全切术的子宫肌瘤患者40例为对照组。术前通过视觉模拟评分法(visual analogue scale/score,VAS)对子宫腺肌病痛经程度评分。用免疫组化法检测2组患者宫颈组织的NGF及PTGFR的表达水平。结果NGF及PTGFR在实验组及对照组的宫颈组织的表达水平差异无统计学意义(P>0.05)。NGF及PTGFR在不同痛经程度的子宫腺肌病痛经患者的宫颈组织中表达水平差异无统计学意义(P>0.05)。结论NGF及PTGFR在子宫腺肌病痛经患者的宫颈组织表达与对照组差异无统计学意义,宫颈组织与子宫腺肌病痛经程度关系不大。
Objective To investigate the expression of nerve growth factor(NGF)and prostaglandinF-2alpha receptor(PTGFR)in cervical tissue of patients with adenomyosis(AM).Methods Forty patients with dysmenorrhea due to adenomyosis were enrolled as experimental group,and 40 patients with uterine myoma without dysmenorrhea who underwent total hysterectomy were enrolled as control group.The severity of dysmenorrhea of patients was evaluated by visual analogue scale/score(VAS)before surgery.Moreover the expression levels of NGF and PTGFR in cervical tissues in both groups were detected by immunohistochemistry.Results There were no significant differences in the expression levels of NGF and PTGFR in cervical tissue between the two groups(P>0.05).There were no significant differences in the expression levels of NGF and PTGFR in cervical tissues of patients with adenomyosis dysmenorrhea with different degrees of dysmenorrhea(P>0.05).Conclusion There are no significant differences in the expression levels of NGF and PTGFR in cervical tissue between the patients with adenomyosis dysmenorrhea and healthy subjects,moreover,the cervical tissues are not closely correlated with the severity of dysmenorrhea due to adenomyosis.
作者
张秀艳
柴亚娟
纪利娜
梁紫影
孙海燕
ZHANG Xiuyan;CHAI Yajuan;JI Lina(Chengde Hospital of Gynecology and Obstetrics,Hebei,Chengde 067000,China)
出处
《河北医药》
CAS
2019年第15期2356-2358,共3页
Hebei Medical Journal
