摘要
目的 探讨局部进展期直肠癌患者行术前放化疗的临床效果,并分析术前放化疗敏感性与BDNF和TrkB表达的关系。方法 选取51例直肠癌患者作为研究对象,所有患者均行术前放化疗治疗;应用免疫组织化学SP法检测治疗前后BDNF和TrkB表达情况。结果 经治疗后,肿瘤病理学表现降期者为39例(76.47%);完全缓解者6例(11.76%)。术前放化疗前后,BDNF和TrkB表达差异无统计学意义(P>0.05);BDNF和TrkB表达与放化疗敏感性无明显关联(P>0.05)。结论 直肠癌患者术前行放化疗可明显缩小肿瘤大小,达到降期效果;经放化疗治疗后,组织中BDNF和TrkB表达无明显变化,因此检测组织BDNF和TrkB表达不能作为评价放化疗敏感性的指标。
Objective To investigate the clinical efficacy of preoperative radiotherapy and chemotherapy in patients with locally advanced rectal cancer,and to analyze the relationship between the sensitivity of preoperative radiotherapy and chemotherapy and the expression of BDNF and TrkB. Methods 51 patients selected for treatment of rectal cancer confirmed by surgical pathology as the subject of this study were treated with preoperative radiotherapy and chemotherapy.Immunohistochemical SP method was used to detect the expression of BDNF and TrkB before and after treatment. Results After treatment,there were 39 cases (76.47%) with tumor pathological deterioration and 6 cases (11.76%) with complete remission.Before and after radiotherapy and chemotherapy,expression of BDNF and TrkB was compared, P >0.05;BDNF and TrkB expression was not significantly correlated with the sensitivity of radiotherapy and chemotherapy, P >0.05. Conclusion Preoperative radiotherapy and chemotherapy for patients with rectal cancer can significantly reduce the size of the tumor and achieve a declining effect.After treatment with radiotherapy and chemotherapy,there is no significant change in the expression of BDNF and TrkB in tissues.Therefore,the detection of BDNF and TrkB expression in tissues can not be used as an evaluation of the sensitivity of radiotherapy and chemotherapy.index.
作者
韩海林
赵岭岭
HAN Hailin;ZHAO Lingling(Fifth People's Hospital of Qinghai,Xining,810000)
出处
《实用癌症杂志》
2019年第6期989-991,共3页
The Practical Journal of Cancer
基金
河北省衡水市科技局项目(编号:2017014039Z)
关键词
BDNF
TRKB
直肠癌
术前放化疗
敏感性
BDNF
TrkB
Rectal cancer
Preoperative radiotherapy and chemotherapy
Sensitivity
