摘要
目的探讨转化生长因子β1(TGF-β1)与人类Runt相关转录因子3(Runx3)在结肠癌中的表达及其两者表达的相关性。方法收集2011年1月至2013年12月安岳县人民医院收治的结肠癌患者34例、结肠腺瘤性息肉患者34例标本以及正常体检的34例结肠黏膜标本,通过免疫组织化学SP法检测Runx3、TGF-β1的表达,分析Runx3与TGF-β1在结肠癌中的相关性。结果 Runx3在结肠癌组织中表达阳性率最低(17.7%,6/34),与结肠黏膜和结肠息肉组织比较差异均有统计学意义(P<0.01)。TGF-β1在结肠癌组织中的阳性表达率为88.3%(30/34),显著高于结肠息肉和结肠黏膜组织,差异均有统计学意义(P<0.01)。结肠癌中TGF-β1与Runx3表达呈负相关(rs=-0.46,P<0.05)。结论 Runx3及TGF-β1在不同结肠组织中表达差异明显,在结肠癌组织中表达有相关性,检测Runx3和TGF-β1可能为结肠癌早期诊断提供一定依据。
Objective To investigate the expression of transforming growth factor-β1（TGF-β1） and Runt-related transcription factor 3（Runx3） in colon cancer,and their correlation.Methods A total of 34 patients with colon cancer and 34 patients with colonic adenomatous polyp admitted in Anyue People＇s Hospital from Jan.2011 to Dec.2013 were selected as research objects,and another 34 cases of normal colon mucosa specimens from physical examination were selected as the normal control,the expression of Runx3 and TGF-β1in the three groups was detected by immunohistochemical method,and correlation between Runx3 and TGF-β1in colon cancer was analyzed.Results The expression of Runx3 in colon cancer tissues was the lowest（17.7%,6/34）,and the differences with the other two groups were statistically significant（P〈0.01）.The positive expression rate of TGF-β1in colon cancer（88.3%,30/34） was significantly higher than that in colonic adenomatous polyp and normal colon mucosa,the differences were statistically significant（P〈0.01）.The expression of TGF-β1and Runx3 in colon cancer were negatively correlated（rs=-0.46,P〈0.05）.Conclusion The expression of Runx3 and TGF-β1in different colon tissues is significantly different,and correlates with each other in colon cancer.Detection of Runx3 and TGF-β1may provide a basis for early diagnosis of colon cancer.
出处
《医学综述》
2015年第7期1317-1318,1321,共3页
Medical Recapitulate
