摘要
目的探讨囊胚解冻移植(FBT)临床结局的相关影响因素。方法选取囊胚移植的患者812例为研究对象。所有患者均采用同一囊胚解冻移植方法,对所有患者女方年龄、男方年龄、基础促卵泡生成激素(FSH)、基础促黄体生成激素(LH)、基础雌二醇(E2)、移植日内膜厚度、不孕类型、装管技师、移植医师、移植囊胚天数、移植胚胎数、移植管类型等信息进行收集。采用χ~2检验或t检验对各因素对患者临床结局的影响进行单因素分析,将单因素分析中差异有统计学意义者进行多因素Logistic分析。结果单因素分析结果显示女方年龄、男方年龄、移植囊胚天数的不同患者FBT临床结局明显不同,差异有统计学意义(P<0.05)。基础FSH、基础LH、基础E2、移植日内膜厚度、不孕因素、装管技师、移植医师、移植胚胎数、移植管类型患者临床结局差异无统计学意义(P>0.05)。多因素分析结果显示:女方年龄(95%CI=4.057,95%CI:1.291～11.576)、男方年龄(95%CI=2.068,95%CI:1.611～6.059)、移植囊胚天数(95%CI=4.086,95%CI:1.015～5.942)为FBT临床结局独立性影响因素(P<0.05)。结论 FBT临床结局受男女双方年龄及移植囊胚天数的影响,如患者同时有第5天和第6天优质胚胎,选择性移植第5天胚胎以提高临床妊娠率。
Objective To explore the related influencing factors of clinical outcome of blastocyst thawing transplantation. Methods 812 patients with blastocyst transplantation in our center were selected as the study subjects .All patients underwent blastocyst thawing transplantation in the same way.The information of age,basal follicle stimulating hormone (FSH),basal luteinizing hormone (LH),basal estradiol (E2),transplantation endometrium thickness,infertility type,tube doctor,transplant doctor,stage of transplanted blastocysts,number of transplanted embryos and the kind of transplation tube were collected. Single-factor analysis was performed on the effect of each factor on the clinical outcomes by chi-square test or t-test. Multivariate Logistic analysis was performed for those with significant differences in single factor analysis. Results Single-factor analysis showed that the clinical outcome was associated with the age and the stage of blastocyst and the difference was statistically significant ( P <0.05).There were no significant differences in the clinical outcome between the basic FSH,the basic LH,the basic E2,the endometrial thickness of the transplant day,the infertility type,the transplant doctor,the number of transplanted embryos,and the kind of transplanted tube ( P >0.05).Multivariate results showed: female age (95% CI =4.057,95% CI :1.291~11.576),male age (95% CI =2.068,95% CI :1.611~6.059) and graft blastocyst days (95% CI =4.086,95% CI :1.015~5.942) were the independent influencing factors of clinical outcome of thawing embryo transplantation ( P <0.05). Conclusion The clinical outcome of thawing blastocyst transplantation is affected by the age of couples and the stage of transplanted blastocysts. For example,Day5 embryos should be transplanted to improve the clinical pregnancy rate for patients with Day5 and Day6 high-quality embryos.
作者
王小雪
邹薇薇
纪冬梅
蒋欢欢
吴欢
曹云霞
Wang Xiaoxue;Zou Weiwei;Ji Dongmei(Reproductive Medicine Center,Dept of Obstetrics and Gynecology,The First Affiliated Hospital of Anhui Medical University,Hefei 230022)
出处
《安徽医科大学学报》
CAS
北大核心
2019年第5期801-804,共4页
Acta Universitatis Medicinalis Anhui
基金
国家重点研发专项(编号:2017YFC1001300)
安徽省自然科学基金(编号:1808085QH273)
关键词
囊胚解冻移植
临床结局
相关因素
blastocyst thawed transplantation
clinical outcome
related factors
