摘要
目的探讨中医证型对原发免疫性血小板减少症(ITP)患者激素治疗反应的预测价值。方法收集2006年12月至2017年12月在新疆维吾尔自治区中医院住院的292例ITP患者资料。诊断均符合中国专家共识,糖皮质激素治疗前进行中医四诊资料采集判断证型。结果 (1)对糖皮质激素治疗前的ITP患者进行中医辨证分型判定,并进行统计分析发现,ITP患者中医证型比例依次为阳虚证>阴虚证>血瘀证>血热证;(2)患者总有效197例,无效95例,总有效率67.47%。但不同中医证型患者对激素的治疗反应具有明显的倾向性,阳虚证患者对激素的治疗反应率为86.61%,分别有60.53%的血热证和60.53%血瘀证对激素治疗有反应,阴虚型患者对激素的治疗反应最差,仅有39.51%。阳虚证、血热证、血瘀证和阴虚证4种证型对激素治疗反应的倾向性差异有统计学意义(χ~2=44.17,P<0.05)。结论阳虚证ITP患者对激素的治疗反应最好。
Objective To explore the predictive value of TCM syndromes in response to hormone therapy in patients with primary immune thrombocytopenia(ITP).Methods A total of 292 patients with ITP thrombocytopenia who were admitted to the hospital from December 2006 to December 2017 were enrolled.The diagnosis accorded with the consensus of Chinese experts.Before the treatment of glucocorticoid,the four diagnostic data of TCM were collected and judged.Results The TCM syndromes of ITP patients before glucocorticoid treatment were classified and analyzed statistically.The proportion of TCM syndromes in ITP patients was Yang-deficiency syndrome>Yin-deficiency syndrome>blood stasis syndrome>blood-heat syndrome.The total effective rate was 67.47%.However,patients with different TCM syndromes had obvious tendency to respond to glucocorticoid therapy.Patients with Yang deficiency syndrome have a response rate of 86.61%to hormones therapy.60.53%of patients with blood-heat syndrome and 60.53%blood stasis syndrome respond to hormone therapy respectively.The response of patients with Yin-deficiency syndrome to hormone therapy was the worst,only 39.51%.There were significant differences in responsing to hormone therapy of the four syndrome(P<0.05).Conclusion The Yang deficiency syndrome ITP patients have the best response to hormone therapy.
作者
白玉盛
李晓征
黄志惠
吴雪琴
马西虎
杜青容
杨茜
吴娟丽
李艳艳
BAI Yusheng;LI Xiaozheng;HUANG Zhihui;WU Xueqin;MA Xihu;DU Qingrong;YANG Qian;WU Juanli;LI Yanyan(Department of Hematology,Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region,Urumqi,Xinjiang 830000,China;Colledge of Traditional Chinese Medicine,Xinjiang Medical University,Urumqi,Xinjiang 830002,China)
出处
《重庆医学》
CAS
2019年第8期1309-1311,共3页
Chongqing medicine
基金
国家自然科学基金资助项目(81560727)
关键词
原发免疫性血小板减少症
中医证型
糖皮质激素类
idiopathic thrombocytopenic purpura
glucocorticoid treatment
TCM syndrome types
glucocorticoids
