摘要
环状RNA(circRNA)是一类通过反向剪接方式形成的具有稳定闭合环状结构的内源性非编码RNA分子,其较线性RNA更保守和稳定,涉及细胞发育、增殖、分化和凋亡,经过长期大规模的研究发现,circRNA的失调与胃癌侵袭、分期、转移和术后复发风险有关。文中对circRNA的结构、分类、功能及其在胃癌中的临床意义进行综述。
Circular RNA(circRNA)is a class of endogenous non-coding RNA molecules with a stable closed loop structure formed by reverse splicing. It is more conserved and stable than linear RNA and involves cell development,proliferation,differentiation and apoptosis. Long-term and large-scale studies show the dysregulation of circRNA is associated with the risk of invasion,staging, metastasis,and postoperative recurrence of gastric cancer. This paper reviews the structure,classification,function of circRNA and its clinical significance in gastric cancer.
作者
吴假假
许利剑
WU Jia-jia (reviewing);XU Li-jian (checking)(Department of General Surgery,the Second Clinical Medicine of Nanjing Medical University,Nanjing 210000,Jiangsu,China)
出处
《医学研究生学报》
CAS
北大核心
2019年第3期331-336,共6页
Journal of Medical Postgraduates
关键词
环状RNA
胃癌
诊断与治疗
circRNA
gastric cancer
diagnosis and treatment
