摘要
胃癌是最常见的消化系统恶性肿瘤,近年发病率不断上升,已成为危害健康的重要疾病。我国由于早期内镜筛查率不高,且缺乏特异的生物标记物,胃癌患者就诊时多处于中晚期。目前晚期胃癌治疗方法包括结合手术治疗的免疫治疗、分子靶向治疗及辅助放化疗等综合治疗手段,但总体治疗效果及预后明显较早期胃癌差,提升胃癌早期诊断率成为促进胃癌预后的重要研究方向。文章主要就临床常用的生物标记物、蛋白标记物、表观遗传学标记物、遗传标记以及其他潜在的生物标记物在胃癌诊断及预后中作用的研究进展进行综述。
As one of the most common malignant tumor of digestive system,gastric cancer has become an important disease threatening people's health with a rising incidence.Due to the low level of early endoscopic screening rate and the lack of specific biomarkers,most of the patients diagnosed with gastric cancers are in the advanced stage.Although the current treatment methods for advanced gastric cancer include immunotherapy combined with surgery,molecular targeted therapy,adjuvant chemoradiotherapy,and other comprehensive treatments,the efficacy and prognosis of advanced gastric cancer are significantly worse than those of early gastric cancer.As a result,improving the early diagnosis rate of gastric cancer has become an important research direction to promote the prognosis of gastric cancer.This article mainly reviews the research progress on the role of common clinical biomarkers,protein markers,epigenetic markers,genetic markers and other potential biomarkers in the diagnosis and prognosis of gastric cancer.
作者
何磊(综述)
许利剑(审校)
HE Lei;XU Li-jian(Department of General Surgery,The Second Affiliated Hospital of Nanjing Medical University,Nanjing 210011,Jiangsu,China)
出处
《医学研究生学报》
CAS
北大核心
2020年第9期1004-1008,共5页
Journal of Medical Postgraduates
关键词
生物标记物
胃癌
诊断
预后
biomarker
gastric cancer
diagnosis
prognosis