摘要
多囊卵巢综合征(PCOS)是困扰女性最常见的生殖内分泌紊乱性疾病,目前认为,PCOS临床表现的复杂性和生化特征的多样性是遗传因素和环境因素共同作用的结果。LncRNAs即长链非编码RNA,其不具有蛋白质编码能力,主要在转录水平、转录后水平和表观遗传水平来发挥其调控功能。LncRNAs是细胞发育、分化、增殖和凋亡的关键调控因子,有研究初步证明LncRNAs可通过卵巢颗粒细胞、高雄激素血症、胰岛素抵抗、肥胖等方面影响着PCOS的发生。本文旨在讨论LncRNAs与PCOS临床表现及其相关疾病之间的关系,为其今后的病因研究提供依据。
Polycystic ovary syndrome(PCOS)is the most common reproductive endocrine disorders in women.It is currently believed that the complexity of the clinical manifestations of PCOS and the diversity of biochemical characteristics are the result of a combination of genetic and environmental factors.LncRNAs,long non-coding RNAs,do not have protein-coding ability;exert its regulatory function mainly at the transcriptional,post transcriptional and epigenetic level.LncRNAs are the key regulator of cell development,differentiation,proliferation and apoptosis.Recently,some studies have shown that LncRNAs may lead to PCOS through many aspects including granulosa cell of ovary,hyperandrogenism,insulin resistance and obesity.This review aims to discuss the relationship between LncRNAs and the clinical manifestations of PCOS and its related diseases to provide a basis for future etiological study.
作者
代会颖
李泽武
杨爱军
DAI Hui-ying;LI Ze-wu;YANG Ai-jun(School of Clinical Meelicine of Jining Medical University,Jining272067;Affiliated Hospital of Jining Medical University,Jining272029)
出处
《生殖医学杂志》
CAS
2019年第2期206-209,共4页
Journal of Reproductive Medicine
