摘要
记忆性T细胞根据其表型特征和功能不同可分为三个亚群即干细胞样T细胞(Tscm)、中心记忆性T细胞(Tcm)和效应记忆性T细胞(Tem)。其中Tscm和Tcm亚群在一些恶性肿瘤的应用中显示出较强的抗肿瘤效应和临床效果,具有了良好的应用前景。因此,研究记忆性T细胞的分化及其体外扩增培养方案等在肿瘤免疫治疗中具有重要意义。本文对记忆性T细胞亚群的表型特征及功能、分化的调控机制以及在临床肿瘤治疗中的应用进行了总结和展望。
It has been clear that memory T cells can be subdivided into phenotypically as well as functionally different subsets:stem memory T cells(Tscm),central memory T cells(Tcm)and effector memory T cells(Tem).The application of Tscm and Tcm cell subsets for some malignancies shows great advantage of anti-tumor ability and clinical efficacy,which have a promising clinical application.Thus,there is great significance in exploring the memory T cell differentiation and expansion in vitro for tumor immunotherapy.Here,we give the summary and expectations about distinct phenotypes,biological functions and differentiation mechanism of different subtypes in memory T cells,as well as the clinical application of memory T cells in tumor therapy.
作者
张震
张毅
ZHANG Zhen;ZHANG Yi(The First Affiliated Hospital of Zhengzhou University,Biotherapy Center,Zhengzhou 450052,China)
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2019年第3期257-262,共6页
Chinese Journal of Immunology
基金
国家自然科学基金项目(No.81771781
U1804281
No.81802857)
国家重点研发计划"重大慢性非传染性疾病防控研究"重点专项项目(2018YFC1313400)
河南省重大科技专项项目(No.161100311000)资助
关键词
记忆性T细胞
分化
功能
肿瘤免疫治疗
Memory T cell
Differentiation
Function
Tumor immunotherapy
