摘要
食管癌是消化系统最常见的恶性肿瘤之一,我国食管癌的发病率及死亡率居世界第1位.目前食管癌的治疗方式主要是内镜、手术、化疗和放疗.这些传统治疗手段虽然取得了一定的临床效果,但对生存期的改善并不明显.目前的多项研究表明,肿瘤免疫微环境在食管癌发生发展中起着很重要的作用.已经完成和正在进行的食管癌免疫治疗的临床试验肯定了免疫治疗在食管癌中的巨大潜力.免疫疗法与现有的或者新的治疗模式相结合将是食管癌治疗的最佳治疗策略.
Esophageal cancer is one of the most common malignant tumors of the digestive system,and China has the highest morbidity and mortality rates of esophageal cancer in the world.Currently,main therapies for esophageal cancer include endoscopy,surgery,chemotherapy,and radiotherapy.These traditional treatments have appreciated clinical effects,but the prognosis of this malignancy is still poor.There is accumulating evidence that tumor immune microenvironment plays a key role in the development and progression of esophageal cancer.Recent clinical investigations and ongoing studies indicate that immunotherapy might have a great potential in the treatment of patients with esophageal cancer.Future studies will identify treatment strategies that can maximize therapeutic benefits by combining immunotherapies with existing and novel treatment modalities.
作者
乔亚敏
张毅
Ya-Nin Qiao Yi Zhang(Biotherapy Center and Cancer Center, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, He＇nan Province, Chin)
出处
《世界华人消化杂志》
CAS
2016年第36期4739-4751,共13页
World Chinese Journal of Digestology
关键词
食管癌
肿瘤免疫微环境
免疫治疗
Esophageal cancer
Tumor immune microenvironment
Immunotherapy
