摘要
目的探讨西药联合止咳化痰宣降汤对小儿支气管炎肺功能及炎性因子的影响。方法选取96例毛细支气管炎患儿,采用随机数字表法分为观察组与对照组,各48例。对照组采用常规治疗,观察组在对照组治疗基础上加用止咳化痰宣降汤治疗。比较2组临床疗效、肺功能改善情况及治疗前后血清中半胱氨酰白三烯(CysLTs)、总Ig E(T-IgE)、嗜酸粒细胞阳离子蛋白(ECP)、呼出气一氧化氮(Fe NO)水平的变化,并记录随访6个月内再次喘息例数。结果治疗后,观察组呼吸困难、咳嗽、喘憋和肺部喘鸣音消失时间均显著短于对照组(P <0. 05)。治疗后,2组患者的潮气量(TV)及达峰时间比(TPTEF/TE)均较治疗前显著升高,呼吸频率(RR)则显著下降(P <0. 05),且观察组TV、TPTEF/TE、RR的变化程度显著大于对照组(P <0. 05)。治疗后,2组患者CysLTs、ECP、Fe NO水平均较治疗前显著降低(P <0. 05),且观察组CysLTs、ECP和Fe NO水平显著低于对照组(P <0. 05)。观察组随访6个月内累计再次喘息患儿例数显著少于对照组(P <0. 05)。观察组总有效率为87. 50%,显著高于对照组总有效率62. 50%(P <0. 05)。结论西药联合止咳化痰宣降汤治疗毛细支气管炎的疗效确切,可有效缓解机体炎症反应,改善患者临床症状。
Objective To investigate the effects of western medicine combined with Cough-relieving and Phlegm-eliminating Xuanjiang Decoction on pulmonary function and inflammation factors of infants with bronchiolitis.Methods A total of 96 infants with bronchiolitis were divided into observation group and control group,with 48 patients per group.The control group was given routine treatment,while the observation group additionally received Cough-relieving and Phlegm-eliminating Xuanjiang Decoction.The clinical efficacy,and improvement of pulmonary function of the two groups were compared.The levels of serum cysteinyl leukotrienes (CysLTs),total Ig E (T-IgE),eosinophil cationic protein (ECP)and fractional exhaled nitric oxide(FeNO)were determined before and after the treatment.The number of recurrence of wheezing was recorded after 6 month follow-up.Results After treatment,the disappearance time of dyspnea,cough and pulmonary rales in the observation group were significantly shorter than that in the control group (P<0.05).Tidal volume (TV) and peak time ratio (TPTEF/TE) of two groups were significantly higher,and respiratory rate was significantly lower than treatment before,while the changes of above indicators in observation group were significantly higher than control group (P<0.05).The levels of CysLTs,ECP and FeNO were significantly decreased after treatment (P<0.05),and the observation group was significantly lower than the control group(P<0.05).The number of recurrence of wheezing in the observation group was less that in the control group (P<0.05).The total effective rate of observation group was 87.50%,which was significantly higher than 62.50% in control group (P<0.05).Conclusion Western medicine combined with Cough-relieving and Phlegm-eliminating Xuanjiang Decoction can relieve the inflammatory response of body,and improve clinical symptoms.
作者
王亚利
WANG Yali(Department of Pediatrics,Weinan Central Hospital,Weinan,Shanxi,714000)
出处
《实用临床医药杂志》
CAS
2019年第2期52-55,59,共5页
Journal of Clinical Medicine in Practice
基金
陕西省卫生厅科研基金项目(2015J432598)
关键词
毛细支气管炎
止咳化痰宣降汤
肺功能
炎性因子
bronchiolitis
Cough-relieving and Phlegm-eliminating Xuanjiang Decoction
pulmonary function
inflammation factors
