摘要
目的观察酚妥拉明联合小儿肺热咳喘口服液治疗婴幼儿毛细支气管炎的临床疗效,并探讨其对肺功能的影响。方法选取2012年5月—2015年2月在武汉市医疗救治中心儿科住院的毛细支气管炎患儿125例,随机分为对照组42例、小儿肺热咳喘口服液组42例、联合组41例。3组患儿均给予常规治疗,小儿肺热咳喘口服液组患儿给予小儿肺热咳喘口服液治疗,联合组患儿给予酚妥拉明联合小儿肺热咳喘口服液治疗,3组患儿均连续治疗7 d。比较3组患儿治疗前后肺功能指标、症状缓解时间(包括退热时间、啰音消失时间、咳嗽消失时间、心力衰竭改善时间)、住院时间及临床疗效,并观察3组患儿治疗期间药物相关不良反应发生情况。结果治疗前3组患儿呼吸频率(RR)、潮气量(TV)和达峰时间比(TPTEF/TE)比较,差异无统计学意义(P<0.05)。治疗后联合组、小儿肺热咳喘口服液组患儿RR低于对照组,TV和TPTEF/TE高于对照组(P<0.05);联合组患儿RR低于小儿肺热咳喘口服液组,TV和TPTEF/TE高于小儿肺热咳喘口服液组(P<0.05)。联合组、小儿肺热咳喘口服液组患儿退热时间、啰音消失时间、咳嗽消失时间、心力衰竭改善时间、住院时间短于对照组,联合组患儿退热时间、啰音消失时间、咳嗽消失时间、心力衰竭改善时间、住院时间短于小儿肺热咳喘口服液组(P<0.05)。联合组患儿临床疗效优于小儿肺热咳喘口服液组和对照组(P<0.05);小儿肺热咳喘口服液组和对照组患儿临床疗效比较,差异无统计学意义(P>0.05)。3组患儿治疗期间均未出现药物相关不良反应。结论酚妥拉明联合小儿肺热咳喘口服液治疗婴幼儿毛细支气管炎的临床疗效确切,能有效改善患儿肺功能、缓解临床症状、缩短住院时间,且安全性较高。
Objective To observe the clinical effect of phentolamine combined with xiaoer feire kechuan oral solution in treating infants with capillary bronchitis,to investigate the impact on pulmonary function. Methods From May 2012 to February 2015,a total of 125 infants with capillary bronchitis were selected in the Department of Pediatrics,Wuhan Medical Center,and they were randomly divided into A group（n = 42）,B group（n = 41）and C group（n = 42）. Infants of the three groups received conventional treatment after admission,and infants of A group received xiaoer feire kechuan oral solution,while infants of B group received phentolamine combined with xiaoer feire kechuan oral solution;all of the three groups were continuously treated for 7 days. Index of pulmonary function before and after treatment,remission time of symptoms（including antifebrile time,disappearance time of rale and cough,improvement time of heart failure）,hospital stays and clinical effect were compared among the three groups,and the incidence of drugs - related adverse reactions during treatment was observed. Results No statistically significant differences of respiratory rate,TV or TPTEE/ TE was found among the three groups before treatment（P ﹥ 0. 05）. After treatment,respiratory rate of A group and B group was statistically significantly lower than that of C group,respectively,while TV and TPTEF/ TE of A group and B group were statistically significantly higher than those of C group （P ﹤ 0. 05）;respiratory rate of B group was statistically significantly lower than that of A group,while TV and TPTEF/ TE of B group were statistically significantly higher than those of A group（P ﹤ 0. 05）. Antifebrile time,disappearance time of rale and cough,improvement time of heart failure and hospital stays of A group and B group were statistically significantly shorter than those of C group,and above index of B group were statistically significantly shorter than those of A group（ P ﹤ 0. 05）. The clinical effect of B group was sta
作者
余西玲
黄晴
YU Xi-ling HUANG Qing(Department of Tuberculosis for Children, Wuhan Medical Center, Wuhan 430000, Chin)
出处
《实用心脑肺血管病杂志》
2016年第6期92-95,共4页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
支气管炎
酚妥拉明
小儿肺热咳喘口服液
治疗结果
肺功能
Bronchopneumonia
Phentolamine
Xiaoer feire kechuan oral solution
Treatment outcome
Pulmonary function
