摘要
目的探讨止咳化痰合剂联合常规治疗对痰热证慢性阻塞性肺疾病急性加重(AECOPD)患者肺功能、可溶性髓样细胞触发受体1(sTREM-1)、血清淀粉样蛋白A(SAA)、可溶性Fms样酪氨酸激酶1(SFLT-1)的影响。方法选择2021年3—8月本院收治的痰热证AECOPD患者80例,按照随机数字表法将患者分为两组。对照组(n=40)采用常规治疗,试验组(n=40)在对照组基础上联合止咳化痰合剂治疗。比较两组临床疗效,治疗前后第1秒用力呼气容积(FEV_(1))占用力肺活量(FVC)百分比(FEV_(1)/FVC)、FEV_(1)占预计值百分比(FEV_(1)%pred),以及治疗前后sTREM-1、SAA、SFLT-1水平。结果试验组治疗总有效率为97.50%,高于对照组的80.00%,差异有统计学意义(P<0.05);治疗后,试验组FEV_(1)/FVC、FEV_(1)%pred分别为(58.81±4.13)%、(65.71±4.09)%,均高于对照组,组间差异有统计学意义(P<0.05);治疗后,试验组sTREM-1、SAA、SFLT-1水平分别为(18.15±5.23)ng/L、(65.48±7.37)pg/mL、(179.20±31.27)ng/L,均低于对照组,组间差异有统计学意义(P<0.05)。结论痰热证AECOPD患者采用常规治疗联合止咳化痰合剂干预可提高临床疗效,改善肺功能,并能减轻机体炎症反应,值得推广。
Objective To investigate the effect of Zhike Huatan Mixture combined with conventional therapy on pulmonary function,serum soluble triggering receptor expressed on myeloid cells-1(sTREM-1),serum amyloid A(SAA),soluble FMS-like tyrosine kinase 1(SFLT-1)in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)with phlegm-heat syndrome.Methods 80 AECOPD patients with phlegm-heat syndrome admitted in the hospital from March to August 2021 were selected,and they were divided into two groups according to the random number table method.The control group(n=40)was treated with for routine treatment,the experimental group(n=40)was treated with Zhike Huatan Mixture on the basis of the control group.The clinical efficacy,forced expiratory volume in one second(FEV_(1))occupied forced vital capacity(FVC)percentage(FEV_(1)/FVC),FEV_(1) as a percentage of expected value(FEV_(1)%pred)before and after treatment,and the levels of sTREM-1,SAA and SFLT-1 after treatment were compared between the two groups.Results The total effective rate of treatment in the experimental group was 97.50%,which was higher than 80.00%in the control group,and the difference was statistically significant(P<0.05);after treatment,the FEV_(1)/FVC and FEV_(1)%pred in the experimental group were(58.81±4.13)%and(65.71±4.09)%,respectively,which were higher than those in the control group,and the differences between the groups were statistically significant(P<0.05);after treatment,the levels of sTREM-1,SAA and SFLT-1 in the experimental group were(18.15±5.23)ng/L,(65.48±7.37)pg/mL,and(179.20±31.27)ng/L,which were lower than those in the control group,and the differences between groups were statistically significant(P<0.05).Conclusion For AECOPD patients with phlegm-heat syndrome,Zhike Huatan Mixture combined with conventional treatment can improve clinical efficacy,improve pulmonary function,and reduce the body's inflammatory response,which is worthy of promotion.
作者
鞠秋燕
JU Qiuyan(Department of Respiratory Medicine,Rugao Hospital of Traditional Chinese Medicine,Rugao Jiangsu,226500,China)
出处
《反射疗法与康复医学》
2022年第2期1-3,共3页
Reflexology And Rehabilitation Medicine
关键词
慢性阻塞性肺疾病
止咳化痰合剂
肺功能
炎性因子
急性加重
Chronic obstructive pulmonary disease
Zhike Huatan Mixture
Pulmonary function
Inflammatory factors
Acute exacerbation
