摘要
为制备具有双重敏感性的水凝胶,以甘蔗渣为主要原料,经过处理后得到纯度较高的蔗渣纤维素(SBC);以SBC和羧甲基纤维素(CMC)为基体制得的SBC/CMC水凝胶作为第一聚合物网络,并在第一聚合物网络的基础上,以N-异丙基丙烯酰胺为单体、N,N'-亚甲基双丙烯酰胺为交联剂、过硫酸铵为引发剂,采用互穿网络聚合物技术形成第二聚合物网络,制得具有互穿网络结构的水凝胶。扫描电镜和红外光谱分析结果表明,水凝胶中两种结构相互独立存在并形成了互穿网络结构。不同温度和p H条件下的溶胀实验结果表明此水凝胶具有p H和温度双敏感性。力学性能测试表明水凝胶具有较好的机械性能,其最大可承受80 k Pa的压缩应力。以牛血清白蛋白作为药物模型,研究了在磷酸缓冲液和模拟胃液环境中水凝胶的药物释放性能,证明p H和温度影响水凝胶药物的释放。
Dual-responsive hydrogel was prepared with sugarcane bagasse cellulose(SBC)extracted from sugarcane bagasse via interpenetrating polymer network(IPN)strategy in this work.The first polymer network was developed by crosslinking SBC with carboxymethyl cellulose(CMC),followed by in-situ polymerization of N-isopropylacrylamide(NIPAm)in the presence of N,N′-methylene bisacrylamide for crosslinking and ammonium persulfate as initiator to form the second network.The results of scanning electron microscopy and infrared spectroscopy for the as-synthesized IPN hydrogel showed that the two structures in hydrogels were independent of each other.The results of swelling experiments at different temperatures and pH showed that the hydrogels had thermal and pH responsive.The mechanical properties of the hydrogels showed that the hydrogels had good mechanical properties and the maximum compressive stress was of 80 kPa.Bovine serum albumin was used as a model drug to study the drug release properties of hydrogels in phosphoric acid buffer and simulated gastric juice.The effects of pH and temperature on the release of drug from hydrogels were confirmed.
作者
王靖淳
蔡平雄
潘远凤
WANG Jing-chun;CAI Ping-xiong;PAN Yuan-feng(College of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China;College of Petroleum and Chemical Engineering, Qinzhou University, Qinzhou 535099, China)
出处
《广西大学学报（自然科学版）》
CAS
北大核心
2018年第6期2383-2390,共8页
Journal of Guangxi University（Natural Science Edition）
基金
国家自然科学基金资助项目(21466005)
关键词
甘蔗渣纤维素
聚(N-异丙基丙烯酰胺)
互穿网络
药物缓释
sugarcane bagasse cellulose(SBC)
poly(N-isopropylacrylamide)(PNIPAm)
interpenetrating polymer network(IPN)
drug release
