摘要
流行病学研究表明,糖尿病是心血管疾病的独立危险因素,糖尿病人群心血管病的发病率是非糖尿病人群的2倍;而2型糖尿病患者心血管疾病高发的原因目前公认的原因包括其所伴随的脂代谢紊乱;而多项国内外实验结果证明,冠状动脉粥样硬化的严重程度与血清中小而密低密度脂蛋白胆固醇(sdLDL-C)的水平呈正相关。因此,对sdLDL-C在2型糖尿病合并冠状动脉粥样硬化患者中的作用的阐述,有利于临床指导sdLDL-C对心血管疾病的预防和治疗。
Epidemiological studies show that diabetes is an independent risk factor for cardiovascular diseases,and the incidence of cardiovascular diseases in diabetes patients is twice as high as that in non-diabetes patients.However,the reasons for the high incidence of cardiovascular diseases in type2diabetes mellitus patients are currently recognized as including the accompanying disorder of lipid metabolism.Many domestic and foreign experimental results prove that the severity of coronary atherosclerosis is positively correlated with the level of medium and small dense low density lipoprotein cholesterol(sdLDL-C)in serum.Therefore,the explanation of the role of sdLDL-C in patients with type2diabetes mellitus and coronary atherosclerosis is helpful to guide the prevention and treatment of cardiovascular diseases by sdLDL-C clinically.
作者
杨雨佳
李川
李莉
YANG Yujia;LI Chuan;LI Li(The Second Clinical Medicine School of China Medical University, Shenyang Liaoning 110000;Department of Endocrinology and Metabolism, Shengjing Hospital of China Medical University, Shenyang Liaoning 110000, China)
出处
《中国继续医学教育》
2018年第35期91-94,共4页
China Continuing Medical Education
关键词
小而密低密度脂蛋白
2型糖尿病
冠状动脉粥样硬化
脂代谢
small dense low density lipoprotein cholesterol
type 2 diabetes mellitus
coronary atherosclerosis
lipid metabolism
