摘要
目的:探讨布地奈德鼻喷雾剂联合孟鲁司特钠治疗变应性鼻炎的疗效。方法:收集我院2013年9月至2015年5月收治的变应性鼻炎患者90例前瞻性研究且随机分为两组,每组45人,A组患者给予布地奈德+氯雷他定,B组患者给予布地奈德+孟鲁司特钠,比较两组患者临床症状评分与治疗效果。结果:A组患者治疗后鼻塞评分(0.81±0.18)、鼻痒评分(0.61±0.19)、喷嚏评分(0.57±0.15)与流涕评分(0.34±0.13)均显著性高于B组(0.56±0.15,0.46±0.11,0.41±0.12,0.21±0.08),存在显著性差异(t=12.451,9.261,7.051,5.337),具有统计学意义(P<0.01);A组患者总有效率(75.56%)明显低于B组(93.33%),存在明显差异(χ2=5.414),具有统计学意义(P<0.05)。结论:相比较布地奈德+氯雷他定的治疗效果,布地奈德+孟鲁司特钠对变应性鼻炎患者治疗最为显著,具有借鉴性。
Objective:To investigate the efficacy of budesonide nasal spray combined with montelukast sodium in the treatment of allergic rhinitis.Methods:90 patients with allergic rhinitis admitted in our hospital from September 2013 to May 2015 were randomly divided into two groups(45 in each group).Patients in group A received budesonide plus loratadine,Group B patients given budesonide+montelukast sodium,clinical symptoms score and treatment effect of two groups were compared.Results:The nasal obstruction score(0.81±0.18),nasal itching score(0.61±0.19),sneezing score(0.57±0.15),and nasal discharge score(0.34±0.13)in group A were significantly higher than those in group B(0.56±0.15,0.46±0.11,0.41±0.12,0.21±0.08),there was significant difference(t=12.451,9.261,7.051,5.337),with statistical significance(P<0.01);The total effective rate in group A(75.56%)Was significantly lower than that in group B(93.33%),there was a significant difference(χ2=5.414),with statistical significance(P<0.05).Conclusion:Comparing the efficacy of budesonide plus loratadine,budesonide+montelukast sodium is the most effective treatment for allergic rhinitis.
作者
詹飞
陈锋
ZHAN Fei;CHEN Feng(Xiangyang Center Hospital Affiliated to Hubei arts and Science College,Hubei Xiangyang 441021,China)
出处
《河北医学》
CAS
2018年第7期1210-1213,共4页
Hebei Medicine
基金
湖北省自然科学基金项目
(编号:2013CBD0355)
关键词
布地奈德
氯雷他定
孟鲁司特钠
疗效
Budesonide
Loratadine
Montelukast sodium
Therapeutic effect
