摘要
目的：探讨通窍鼻炎颗粒联合孟鲁司特钠、布地奈德治疗变应性鼻炎（AR）临床疗效及对白细胞介素-6（IL-6）、白细胞介素-8（IL-8）、白细胞介素-10（IL-10）的影响。方法 ：选取2014年10月-2015年10月河北钢铁集团宣钢职工医院就诊的50例AR患者为研究对象,随机分为观察组与对照组。对照组给予口服孟鲁特钠10mg/次,1次/d,布地奈德喷剂64μg/次,2次/d喷鼻;观察组在对照组基础上口服通窍鼻炎颗粒2g/次,3次/d,两组均连续用药3周。对比观察治疗前后临床症状评分、临床治疗效果及对血清IL-6、IL-8、IL-10的影响。结果：治疗后,两组喷嚏、鼻塞、鼻痒、流涕症状积分均降低,观察组优于对照组（P〈0.05）;总有效率观察组为96.0%,优于对照组的80.0%,差异有统计学意义（P〈0.05）;治疗后,两组IL-6、IL-8水平升高,IL-10降低,观察组优于对照组（P〈0.05）。结论：通窍鼻炎颗粒联合孟鲁司特钠、布地奈德治疗AR疗效可靠,能够有效减轻炎性反应,显著改善临床症状,值得临床推广。
Objective：To explore the clinical efficacy of Tongqiao Biyan granule in combined with montelukast sodium and budesonide in the treatment of allergic rhinitis（AR）and their effects on IL-6,IL-8,and IL-10.Methods：A total of 50 patients with AR who were admitted in our hospital from October,2014 to October,2015 were included in the study and randomized into the observation group and the control group.The patients in the control group were orally given montelukast sodium,10mg/time,1time/d,and budesonide spray,64μg/time,2 times/d for nasal spray.On this basis,the patients in the observation group were given Tongqiao Biyan granules,2g/time,3times/d.A continuous 3-week treatment was given in the two groups.The clinical symptom scores,the clinical therapeutic effect,and the effect on serum IL-6,IL-8,and IL-10 before and after treatment in the two groups were observed and compared.Results：After treatment,the symptom scores of sneeze,stuffy nose,rhinocnesmus,and running nose in the two groups were reduced,and the reduced degree in the observation group was more significantly（P〈0.05）.The total effective rate in the observation group（96.0%）was significantly higher than that in the control group（80.0%）（P〈0.05）.After treatment,the levels of IL-6and IL-8in the two groups were elevated,while IL-10 level was reduced,and those in the observation group were significantly superior to those in the control group（P〈0.05）.Conclusions：Tongqiao Biyan granule in combined with montelukast sodium and budesonide in the treatment of AR can effectively alleviate the inflammatory reaction,and significantly improve the clinical symptoms with a reliable efficacy;therefore,it deserves to be widely recommended in the clinic.
出处
《海南医学院学报》
CAS
2016年第11期1170-1172,共3页
Journal of Hainan Medical University
基金
宣钢集团科技进步项目(2014056305)~~
