摘要
目的探讨通心络胶囊(人参、水蛭、全蝎等)联合常规治疗对适行冠状动脉搭桥(CABG)手术患者纤维蛋白原(Fib)、平均血小板体积(MPV)水平的影响。方法 106例患者随机分为对照组(50例)和观察组(56例),对照组采用常规治疗,观察组在常规治疗基础上加用通心络胶囊。比较2组Fib、MPV水平,并评价治疗的安全性。结果治疗30、90 d后,2组复合心血管终点事件(顽固性心绞痛+再发心肌梗死+死亡)均显著减少(P<0.01)。与对照组比较,观察组血浆Fib水平下降更明显(P<0.01)。治疗后,2组MPV水平均较治疗前显著下降(P<0.05);90 d后,观察组MPV水平下降程度比对照组更明显(P<0.05)。观察组和对照组出血事件发生率分别为5.4%和4.0%。结论通心络胶囊可增强适行CABG手术患者抗栓疗效,改善临床症状,无严重出血风险。
AIM To investigate the effects of Tongxinluo Capsules(Ginseng Radi%et Rhizoma,Hirudo,Scorpio,etc.)combined with routine treatment on fibrinogen(Fib)and mean platelet volume(MPV)levels in appropriate patients for coronary artery bypass graft(CABG)surgery.METHODS One hundred and six patients were randomly assigned into control group(71=50)for routine treatment and observation group(n=56)for combination therapy of Tongxinluo Capsules and routine treatment.Both groups had their Fib and MPV levels evaluated,and safety compared.RESULTS Thirty,ninety days after the treatment,the two groups reported less incidence of composite cardiovascular events(refractory angina pectoris,relapsing myocardial infarction or death)(P<0.01),and the observation group had an even more obviously reduced plasma Fib level(P<0.01).The significantly decreased after-treatment MPV levels in the two groups were observed(P<0.05),and a most distinct decrease extent was found in the observation group after 90 d(P<0.05).For the bleeding events,the incidence rates of the observation group and the control group were 5.4%and 4.0%,respectively.CONCLUSION For appropriate candidates of CABG surgery,Tongxinluo Capsules shows its efficacy in dissolving thrombus and improving clinical symptoms without serious bleeding risk.
作者
李秀芬
杨燕
乔瑞
帕尔哈提·吐尔逊
LI Xiu-fen;YANG Yan;QIAO Rui;PERHAT Tur-sun(Cardiac Care Center,Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical University,Ummqi 830001,China)
出处
《中成药》
CAS
CSCD
北大核心
2018年第3期558-561,共4页
Chinese Traditional Patent Medicine
