摘要
目的:分析纤维蛋白原(fibrinogen,FIB)、尿酸、脂蛋白在急性脑梗死中的表达。方法:选取2019年2月-2020年9月于苏州市相城人民医院接受治疗的急性脑梗死患者130例为研究组,另选取同期于本院进行健康体检的志愿者70例为对照组。比较研究组和对照组的FIB、尿酸、脂蛋白水平。根据患者不同脑梗死灶面积分为大梗死灶、中梗死灶、小梗死灶。将研究组患者根据颈动脉斑块是否稳定分为稳定斑块、不稳定斑块;根据不同程度神经功能损伤将患者分为轻度神经功能损伤、中度神经功能损伤、重度神经功能损伤;根据颈动脉斑块的严重程度将患者分为Ⅰ、Ⅱ、Ⅲ级。比较上述患者的FIB、尿酸、脂蛋白水平。结果:研究组FIB、尿酸、脂蛋白水平均明显高于对照组(P<0.05)。与小梗死灶患者相比,中梗死灶患者FIB、尿酸、脂蛋白水平均有所上升(P<0.05);与中梗死灶患者相比,大梗死灶患者FIB、尿酸、脂蛋白水平均有所上升(P<0.05)。与轻度神经功能损伤患者相比,中度神经功能损伤患者FIB、尿酸、脂蛋白水平均上升(P<0.05);与中度神经功能损伤患者相比,重度神经功能损伤患者FIB、尿酸、脂蛋白水平均上升(P<0.05)。与稳定斑块患者相比,不稳定斑块患者FIB、尿酸、脂蛋白水平均有所上升(P<0.05);与Ⅰ级斑块患者相比,Ⅱ级斑块患者FIB、尿酸、脂蛋白水平均上升(P<0.05);与Ⅱ级斑块患者相比,Ⅲ级斑块患者FIB、尿酸、脂蛋白水平均上升(P<0.05)。结论:FIB、尿酸、脂蛋白在急性脑梗死患者中均呈高表达,在大梗死灶、重度神经功能损伤、不稳定斑块患者中表达最高。
Objective:To analyze the expression of fibrinogen(FIB),uric acid and lipoprotein in acute cerebral infarction.Method:A total of 130 patients with acute cerebral infarction who received treatment in Xiangcheng People’s Hospital,Suzhou City from February 2019 to September 2020 were selected as the study group,and 70 volunteers who received physical examination in our hospital during the same period were selected as the control group.FIB,uric acid and lipoprotein levels were compared between the study group and the control group.Patients in the study group were divided into stable plaque and unstable plaque according to whether carotid plaque was stable;patients were divided into mild,moderate and severe neurological impairment according to different degrees of neurological impairment;patients were divided into gradeⅠ,ⅡandⅢaccording to the severity of carotid plaque.The levels of FIB,uric acid and lipoprotein were compared.Result:The levels of FIB,uric acid and lipoprotein in the study group were significantly higher than those in the control group(P<0.05).Compared with the patients with small infarct,the levels of FIB,uric acid and lipoprotein were increased in the patients with medium infarct(P<0.05);compared with patients with moderate infarct,FIB,uric acid and lipoprotein levels were increased in patients with large infarct(P<0.05).Compared with patients with mild neurological injury,the levels of FIB,uric acid and lipoprotein in patients with moderate neurological injury were increased(P<0.05);compared with patients with moderate neurological injury,the levels of FIB,uric acid and lipoprotein in patients with severe neurological injury increased(P<0.05).Compared with stable plaque patients,FIB,uric acid and lipoprotein levels in unstable plaque patients were increased(P<0.05).Compared with the patients with gradeⅠplaque,the levels of FIB,uric acid and lipoprotein in patients with gradeⅡplaque were increased(P<0.05);compared with patients with gradeⅡplaque,the levels of FIB,uric acid and lipoprotei
作者
郑成
李永安
ZHENG Cheng;LI Yongan(Xiangcheng People’s Hospital,Suzhou City,Jiangsu Province,Suzhou 215000,China;不详)
出处
《中国医学创新》
CAS
2022年第5期140-144,共5页
Medical Innovation of China
关键词
急性脑梗死
颈动脉斑块
纤维蛋白原
尿酸
脂蛋白
Acute cerebral infarction
Carotid plaque
Fibrinogen
Uric acid
Lipoprotein
