摘要
目的探讨生长抑素联合泮托拉唑钠对重症急性胰腺炎(SAP)患者腹痛缓解时间及血清淀粉酶(AMY)、白细胞计数(WBC)水平变化的影响。方法选取2014年5月至2016年2月邓州市中心医院84例SAP患者,随机数字表法分组,各42例。对照组采用泮托拉唑钠治疗,观察组予以生长抑素联合泮托拉唑钠治疗,均治疗7 d。统计对比两组临床疗效、症状消失时间,对比两组血清AMY、WBC水平及相关炎性因子白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hsCRP)水平变化。结果观察组腹痛缓解时间、肠道功能恢复时间、拔除胃管时间均短于对照组,差异有统计学意义(P<0.05);治疗后观察组血清AMY、WBC水平均较治疗前降低,差异有统计学意义(P<0.05);治疗后观察组血清IL-8、TNF-α、hs-CRP水平均低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率4.76%(2/42)低于对照组21.43%(9/42),差异有统计学意义(P<0.05)。结论生长抑素联合泮托拉唑钠治疗SAP,可有效抑制患者机体炎症反应,能降低血清AMY、WBC水平,促进患者症状恢复,效果显著,值得临床推广。
Objective To investigate the effect of somatostatin combined with pantoprazole sodium on abdominal pain relief time and serum amylase(AMYand white blood cell count(WBCin patients with severe acute pancreatitis(SAP).Methods From April2014to February2016,selected84patients with SAP in the central hospital of Dengzhou were randomly divided into control group and observation group,each group42cases.The control group was treated with pantoprazole sodium,and the observation group was treated with somatostatin and pantoprazole sodium for7days.Clinical efficacy,symptoms disappeared were statistically compared between the two groups,and serum AMY,WBC levels and related inflammatory factors[interleukin-8(IL-8),tumor necrosis factor-琢(TNF-琢and hypersensitive C-reactive protein(hs-CRPlevels were compared between the two groups.Results The abdominal pain relief time,intestinal function recovery time,removal of gastric tube time in the observation group were significantly shorter than those in the control group(P约0.05);The levels of serum AMY and WBC in the observation group after treatment were significantly lower than those before treatment(P约0.05);The levels of serum IL-8,TNF-琢and hs-CRP in the observation group were lower than those in the control group after treatment(P约0.05);The incidence of adverse reactions in the observation group4.76%(2/42was low原er than that in the control group(21.43%,9/42),the difference was statistically significant(P约0.05).Conclusion Somatostatin combined with pantoprazole sodium in the treatment of SAP can effectively inhibit the inflammatory response of patients,can reduce serum AMY,WBC levels,and promote the recovery of patients with symptoms,the effect is remarkable,worthy of promotion.
作者
刘晓东
巴书礼
王亚平
Liu Xiaodong;Ba Shuli;Wang Yaping(Dengzhou Central Hospital,Department of gastroenterology,Dengzhou 474150,China)
出处
《哈尔滨医药》
2018年第1期12-13,16,共3页
Harbin Medical Journal
