摘要
目的探讨奥曲肽联合加贝酯治疗重症急性胰腺炎(SAP)的效果及其对血清尿胰蛋白酶原-2的影响。方法将80例SAP患者随机均分为两组。对照组仅采用奥曲肽治疗,观察组在此基础上采用加贝酯治疗。比较两组患者临床疗效、两组治疗前后血清免疫球蛋白的变化、内毒素、炎性因子水平变化、生化指标水平变化以及血清、尿胰蛋白酶原-2阳性率。结果 1观察组临床总有效率为85.00%,显著高于对照组62.50%(P<0.05);2观察组治疗后Ig G及Ig M水平均显著高于对照组(P<0.05),但是两组治疗前后Ig A水平差异无统计学意义(P>0.05);3两组治疗后内毒素、肿瘤坏死因子(TNF-α)、白介素6(IL-6)及C反应蛋白(CRP)较治疗前均显著降低,IL-10较治疗前显著升高,且两组治疗后上述指标差异均具有统计学意义(P<0.05);4两组治疗后淀粉酶及LDH水平均显著低于治疗前(P<0.05),观察组治疗后ALB水平显著高于对照组治疗后(P<0.05);5两组治疗后血清尿胰蛋白酶原-2阳性率均显著低于治疗前(P<0.05),且观察组治疗后血清尿胰蛋白酶原-2阳性率显著低于对照组治疗后(P<0.05)。结论奥曲肽联合加贝酯治疗SAP显著,可有效降低血清尿胰蛋白酶原-2、炎性因子、淀粉酶、LDH、血清、尿胰蛋白酶原-2水平,提高临床疗效,值得在临床上推广应用。
Objective To investigate the octreotide gahexate treatment of severe acute pancreatitis （SAP） and its effect on serum urine trypsinogen - 2. Methods 80 patients with SAP in accordance with the treatment of patients were randomly divided into control group and obser- vation group. The control group received octreotide treatment, observation group added gabexate treatment on this basis. Comparison of the clinical efficacy of the two groups was performed, before and after treatment, serum immunoglobulin treatment before and after toxin levels of inflammatory factors, biochemical marker levels before and after treatment, changes before and after treatment serum, urine trypsinogen -2 positive rate. Restilts ①The total effective rate in clinical observation group was 85.00%, which was significantly higher than 62.50% （ P 〈 0.05 ）. ②The lgG and IgM of post - treatment observation group were significantly lower than the control group （ P 〈 0.05 ） , hut not statistically significant （ P 〉 0.05 ）. The lgA level was different between the two groups before and after treatment. ③The endotoxin, TNF - α, IL - 6 and CRP before treatment were significantly lower, IL - 10 level significantly increased before and after treatment, these indicators were statistically significant differences （ P 〈 0.05 ）. ④The amylase and LDH levels were significantly lower than before treatment （ P 〈 0.05 ） , the ALB levels after treat- ment in the observation group was significantly higher （ P 〈 0.05 ）. ⑤The serum urine trypsinogen - 2 positive rate after treatment was signifi- cantly lower than before treatment （ P 〈 0.05 ）. The serum urine trypsinogen - 2 positive rate in the observation was significantly lower than in the control group （ P 〈 0.05 ）. Conclusion Above all octreotide combined with gabexate treatment of SAP can effectively reduce urinary trypsin - 2, serum inflammatory factor, amylase, LDH, serum, urinary trypsin - 2 levels. This method should be popularized and applied i
出处
《临床和实验医学杂志》
2015年第23期1971-1975,共5页
Journal of Clinical and Experimental Medicine
