摘要
目的探讨胰岛素与西格列汀联合用药方案治疗老年2型糖尿病的有效性和安全性,为临床医师选择合理用药方案提供参考。方法随机选取本院于2015年1月～2017年11月期间收治老年2型糖尿病患者82例作为研究对象,根据患者入院序号奇偶数按比例(1∶1)划分为对照组和观察组,每组患者41例,对照组给予胰岛素治疗,观察组在此基础上联合应用西格列汀治疗,观察对比两组患者临床疗效、血糖水平和安全性。结果治疗2个月后,观察组患者治疗总有效率为92.68%明显高于对照组73.61%(P<0.05);治疗前空腹血糖(FPG)、餐后2 h血糖(2 hPBG)、糖化血红蛋白(HbA1c)组间比较差异无统计学意义,治疗2个月后上述指标均明显降低,且观察组低于对照组(P<0.05);治疗2个月后观察组患者不良反应发生率为4.88%低于对照组19.52%(P<0.05)。结论针对老年2型糖尿病患者,给予胰岛素联合西格列汀治疗能够改善患者血糖状态,较单纯胰岛素治疗疗效确切,且安全性较高,值得广泛推广。
Objective To explore the efficacy and safety of insulin combined with sitagliptin in the treatment of elderly type 2 diabetes mellitus, and to provide a reference for clinicians in choosing a reasonable drug regimen. Methods 82 elderly patients with type 2 diabetes mellitus treated in Chaoyang County Central Hospital were randomly selected from January 2015 to November 2017. According to the odd and even numbers of admission numbers, the patients were divided into control group and observation group （1 ： 1） with 41 cases in each group. The control group was treated with insulin, and the observation group was treated with insulin ＋ sitagliptin. The clinical efficacy, blood glucose level and safety of the two groups were observed and compared. Results After 2 months of treatment, the total effective rate was 92.68% in the observation group, which was significantly higher than that in the control group （73.61%） （P〈0.05）. Before treatment, there was no significant difference in fasting blood glucose （FPG）, postprandial blood glucose （2 h PBG） and glycosylated hemoglobin （HbAlc） between two groups. After 2 months of treatment, the above indexes in the observation group were significantly lower than that in the control group （P〈0.05）; and the incidence of adverse reactions in the observation group was 4.88%, lower than that in the control group 19.52% （P〈0.05）. Conclusion For elderly patients with type 2 diabetes mellitus, insulin combined with sitagliptin treatment can improve blood glucose status, more effective than simple insulin treatment, and higher safety, it is worth promoting widely.
作者
姜丽华
Jiang Lihua(Department of Internal Medicine,Chaoyang County Central Hospital,Chaoyang,Liaoning,122000,China)
出处
《当代医学》
2018年第33期93-95,共3页
Contemporary Medicine
关键词
老年2型糖尿病
胰岛素
西格列汀
临床疗效
安全性
Elderly type 2 diabetes mellitus
Insulin
Sitagliptin
Clinical efficacy
Safety
