摘要
目的探讨西格列汀联合预混胰岛素对2型糖尿病(T2DM)的疗效及对血糖波动的影响。方法选取2014年6月至2015年6月该院内分泌科T2DM患者60例,将其分为对照组和观察组(各30例),对照组给予门冬胰岛素30注射液治疗,观察组给予西格列汀联合门冬胰岛素30注射液治疗,检测患者治疗前后空腹血糖(FPG)、餐后2h血糖(2hPG)、糖化血红蛋白(HbA1c)、空腹血清C肽(FCP)、餐后2hC肽(2hCP)、HOMA胰岛素抵抗指数(HOMA-IR)、HOMA胰岛β细胞功能指数(HOMA-HBCI)、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白(LDL)和高密度脂蛋白(HDL)。结果治疗后,观察组FPG、2h PG和HbA1c水平均低于对照组,差异均有统计学意义(P<0.01);观察组2hCP水平高于对照组,LDL水平和HOMA-IR值均低于对照组,差异均有统计学意义(P<0.05或P<0.01);观察组午餐前1h、晚餐前1h、早餐后3h、午餐后3h和晚餐后3h血糖水平均低于对照组,差异均有统计学意义(P<0.01)。结论西格列汀联合预混胰岛素对T2DM具有更好的降血糖作用,且患者的血糖更为稳定。
Objective To explore the clinical efficacy of combined use of sitagliptin and premixed insulin for the treatment of type 2 diabetes mellitus（T2DM） and its effects on blood sugar fluctuations. Methods A total of 60 cases of patients with T2DM who treated in the department of endocrinology of our hospital from June 2014 to June 2015 were selected and divided into the control group and observation groups（30 cases in each group）. The control group received insulin aspart 30 injection treatment, the observation group received sitagliptin combined with insulin aspart 30 injection therapy. The fasting blood glucose（FPG）, postprandial 2 h blood glucose（2 h PG）, glycosylated protein glucose（HbAlc）, fasting serum C-peptide（FCP）, postprandial 2 h C peptide（2 h CP）, HOMA-IR, HOMA-HBCI,TG,TC,LDL and HDL before and after the treatment were detected. Results After treatment, the levels of FBG,2 h PG and HbAlc in the observation group were significantly lower than those in the control group （P〈0.01） ;the level of 2 h CP was higher than that in the control group,and the level of LDL and HOMA-IR value were higher than those in the control group（P〈0.05 ,P〈0.01）. The levels of MGB at 1 h before lunch,1 h before dinner,3 h after breakfast,3 h after lunch and 3 h after dinner in the observation group were significantly lower than those in the control group（P〈0.01）. Conclusion Sitagliptin combined wuth premixed insulin has a better hypoglyeemic effect for T2DM, which could control blood glucose more stable.
出处
《重庆医学》
CAS
北大核心
2016年第35期4989-4991,共3页
Chongqing medicine
关键词
西格列汀
预混胰岛素
糖尿病
2型
血糖波动
sitagliptin
pre mixed insulin
diabetes mellitus,type 2
blood glucose fluctuation
