摘要
目的探讨德谷门冬双胰岛素联合西格列汀治疗二甲双胍控制不佳老年2型糖尿病的临床效果。方法选取2020年1月—2021年4月福建省古田县医院接诊106例二甲双胍控制不佳的老年2型糖尿病患者为研究对象,按随机数表法分为两组,每组53例。对照组予以西格列汀治疗,观察组予以德谷门冬双胰岛素联合西格列汀治疗,观察比较两组总体疗效、血糖水平及治疗安全性。结果观察组总有效率为96.23%,明显高于对照组的84.91%,差异有统计学意义(P<0.05)。治疗后,相较于对照组,观察组空腹血糖(FPG)、糖化血红蛋白(HbA1c)、餐后2 h血糖(2 hPG)水平下降更明显,差异有统计学意义(P<0.05)。两组不良反应发生率(11.32%vs 9.43%)比较,差异无统计学意义(P>0.05)。结论二甲双胍控制不佳的老年2型糖尿病患者接受德谷门冬双胰岛素联合西格列汀治疗,能促进血糖改善,提高疗效,且安全性良好。
Objective To investigate the clinical effect of Insulin Degludec and Insulin Aspart combined with sitagliptin in the treatment of type 2 diabetes in elderly patients with poor control of metformin.Methods A total of 106 elderly patients with type 2 diabetes with poor metformin control admitted to Gutian County Hospital of Fujian Province from January 2020 to April 2021 were selected as the study objects,and divided into two groups according to random number table method,with 53 cases in each group.The control group was treated with sitagliptin,and the observation group was treated with Insulin Degludec and Insulin Aspart combined with sitagliptin.The overall efficacy,blood glucose level and treatment safety of the two groups were observed and compared.Results The total effective rate of the observation group was 96.23%,which was significantly higher than that of the control group(84.91%),and the difference was statistically significant(P<0.05).After treatment,compared with the control group,fasting blood glucose(FPG),glycosylated hemoglobin(HbA1c)and 2-hour postprandial blood glucose(2 hPG)levels in the observation group decreased more significantly,the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(11.32%vs 9.43%)(P>0.05).Conclusion In elderly patients with type 2 diabetes with poor metformin control,Insulin Degludec and Insulin Aspart combined with sitagliptin can promote the improvement of blood glucose and improve the efficacy,with good safety.
作者
李文闻
郑晨曦
LI Wenwen;ZHENG Chenxi(Department of Endocrinology,Gutian County Hospital,Gutian,Fujian Province,352200 China;Department of Cardiovascular Medicine,Gutian County Hospital,Gutian,Fujian Province,352200 China)
出处
《糖尿病新世界》
2023年第6期87-90,共4页
Diabetes New World Magazine
关键词
2型糖尿病
二甲双胍
德谷门冬双胰岛素
西格列汀
Type 2 diabetes mellitus
Metformin
Insulin Degludec and Insulin Aspart
Sitagliptin
