摘要
目的探讨血清C反应蛋白(CRP)水平与梅毒甲苯胺红不加热血清试验(TRUST)滴度阳性患者临床分期的关系。方法选取2013年12月～2016年12月佛山市第三人民医院确诊的TRUST滴度阳性患者200例,依据临床分期分为Ⅰ期组(n=90例)、Ⅱ期组(n=70例)和Ⅲ期组(n=40例),所有患者给予TRUST检查,采用酶联免疫吸附法检测血清CRP水平,统计分析所有患者TRUST滴度、临床分期和血清CRP水平。结果在TRUST滴度方面,Ⅰ期组和Ⅲ期组主要分布在1∶4和1∶8,Ⅱ期组主要分布在1∶8和1∶16,Ⅰ期组、Ⅱ期组、Ⅲ期组平均值为[1∶(6.87±3.41)]、[1∶(11.97±3.78)]、[1∶(7.54±3.52)],三组差异均有统计学意义(χ~2=16.571,13.247,t=8.948,6.060,F=22.142,35.576,P均<0.05),但Ⅰ期组和Ⅲ期组比较,差异无统计学意义(χ~2=2.672,P=0.864;t=1.024,P=1.087);在血清CRP水平方面,Ⅱ期组[(58.67±6.44)mg/L]明显高于Ⅲ期组[(15.74±2.67)mg/L]和Ⅰ期组[(33.48±4.72)mg/L],Ⅰ期组明显高于Ⅲ期,且Ⅲ期组接近正常临界值(10mg/L),差异有统计学意义(t=29.546,22.213,40.171,F=68.790,均P<0.05),血清CRP水平、TRUST滴度与患者临床分期呈"∩"型分布关系。结论 TRUST滴度分布在梅毒TRUST滴度阳性患者不同临床分期中存在重叠,而血清CRP水平与患者临床分期关系密切,提示其对指导临床治疗具有重要的参考作用。
Objective To discuss the relationship between serum toluidine red unheated serum test （TRUST） drop degrees, C-reactive protein （CRP） level and clinical stages in patients with syphilis. Methods 200 syphilis patients with positive TRUST drop degrees were selected from December 2013 to December 2016 in the Third People＇s Hospital of Foshan city, according to the random distribution. All patients were divided into Ⅰ period group （n =90） , Ⅱ period group （n= 70） , Ⅲ period group （n =40） ,all patients were given TRUST checking,the serum CRP level was detected by enzyme-linked immunosorbent method,statistical analyzed all patients of TRUST degree,clinical stage and serum CRP levels. Results In terms of TRUST drops degree, Ⅰ period group and Ⅲ period group were mainly distributed in 1 ： 4 and 1：8, Ⅱ period group were mainly distributed in 1 ： 8 and 1 ： 16. The average value of Ⅰ period group, Ⅱ period group and Ⅲ period group were [1 ： （6.87±3.41）],[1 ： （11. 97±3. 78）] and [1 ： （7.54±3.52）],and the difference of tree groups was statistically significant （x2= 16. 571,13. 247,t= 8.948,6.060,F =22. 142,35.576,all P〈0.05）,but difference of Ⅰ period group and Ⅲ period group was no statistically significant （x2= 2. 672, P= 0. 864; t =1. 024, P= 1. 087）. In terms of serum CRP level, Ⅱ period group [（58.67±6.44）mg/L] was obviously higher than that of Ⅲ period group [（15.74±2.67）mg/L] and Ⅰ period group [（33.48±4. 72）mg/L], Ⅰ period group was obviously higher than that of Ⅲ period group,and Ⅲ period group was closed to normal threshold （10 mg/L）, the difference was statistically significant （t =29. 546,22. 213,40. 171, F= 68. 790, all P〈 0.05）, the distribution relationship of serum CRP level, TRUST degree and clinical stages were show the ＂ ∩ ＂ type. Conclusion TRUST drops distribution had overlaps exist in different clinical stages of syphilis patients with positive TRUST drop degrees, and the serum
作者
李永生
陈家强
谢筱颖
陈凯婷
LI Yong -sheng,CHEN Jia -qiang,XIE Xiao -ying,CHEN Kai -ting(Department of Clinical Laboratory, the Third People＇ s Hospital of Foshan, Guangdong Foshan 528000, China)
出处
《现代检验医学杂志》
CAS
2018年第6期157-160,共4页
Journal of Modern Laboratory Medicine
基金
佛山市卫生和计划生育局医学科研课题:肠道菌群与老年首发精神分裂症相关性研究及其作用机制的初步探索(20170134)
