摘要
【目的】分析广东省2005-2014年梅毒流行趋势和疾病负担,为全面认识梅毒的危害性、合理制定卫生政策提供参考。【方法】利用广东省2005-2014年梅毒病例报告数据和广东省人口数据,分别以发病率和伤残调整寿命年（DALY）为分析指标,对广东省不同年份、不同性别、不同年龄组的梅毒疫情和疾病负担进行分析比较。【结果】梅毒报告发病率从2005年的21.08/10万,增长到2014年的52.55/10万,梅毒疾病负担强度从2005年的2.00 DALYs/10万,增长到2014年的3.16DALYs/10万。一期和二期梅毒在全部梅毒病例所占的构成比不断减少,而隐性梅毒的构成比不断增加。虽然三期和胎传梅毒的发病率很低,但其所致疾病负担却远远高于其他分期梅毒。隐性梅毒女性发病率高于男性,但各分期梅毒所致疾病负担均是男性高于女性。一期和二期梅毒的发病高峰为20~35岁,隐性梅毒有两个发病高峰,一个是20~35岁,另一个是60岁及以上年龄人群。【结论】广东省梅毒疫情形势严峻,梅毒疾病谱已经发生改变,隐性梅毒病例占大多数,三期和胎传梅毒发病率处于较低水平,但其所致疾病负担巨大。本研究提示要把各分期梅毒的防控工作放在同等重要的位置上。
【Objective】 To analyze the epidemiological trend and disease burden of syphilis during 2005-2014 in Guangdong Province so as to comprehensively realize the harm of syphilis and provide reference material for making reasonable health policies.【Methods】 The reported syphilis cases and population data from 2005 to 2014 in Guangdong Province were collected. Incidence rate and Disability-Adjusted Life Years（DALY） were both applied to compare the epidemic situation and disease burden of syphilis among different years, genders and age groups. 【Results】 The reported syphilis incidence rate increased yearly from 21.08 / 100 000 in 2005 to 52.55 / 100 000 in 2014 while the disease burden of syphilis increased from 2.00 DALYs / 100 000 in 2005 to 3.16 DALYs / 100 000 in 2014. The proportion of primary and secondary syphilis in all the syphilis cases had declined yearly, but latent syphilis was exact the opposite. Although the incidence rates of tertiary and congenital syphilis were very low, the disease burden due to them was much higher than any other stage of syphilis. The incidence rate of female was higher than male in latent syphilis, but the disease burden of male was higher than female in every stage of syphilis. The incidence rate of primary and secondary syphilis was highest in the age of20-35 years, while latent syphilis was highest in the age of 20-35 years and in the population aged 60 years. 【Conclusion】 The epidemic situation of syphilis in Guangdong Province was severe. The spectrum of syphilis had changed, most of which was latent syphilis. The incidence rates of tertiary and congenital syphilis were low, however, the disease burden due to them was extremely high. This study suggested that the prevention and control of every stage of syphilis should be put in coequal and significant position.
出处
《中山大学学报（医学科学版）》
CAS
CSCD
北大核心
2016年第1期142-147,共6页
Journal of Sun Yat-Sen University:Medical Sciences
基金
广东省皮肤性病中心课题(71020228)
国家卫计委课题(5100041090046)
关键词
梅毒
发病率
伤残调整寿命年(DALY)
流行趋势
疾病负担
syphilis
incidence rate
Disability-Adjusted Life Years（DALY）
epidemiological trend
disease burden
