摘要
原发性肝细胞癌是常见的严重威胁人类健康的恶性肿瘤之一,我国是肝癌大国,其发病率及死亡率均居各种肿瘤的前列,严重损害了国民健康,加重了国民经济负担。由于肝癌细胞的生物侵袭性强,肝癌极容易发生转移,严重影响患者的预后和生活质量。近年来,许多研究发现NF-κB信号通路与肝癌的侵袭转移密切相关,其激活后可通过促进肿瘤血管生成,诱导细胞外基质的降解等途径促使肝癌细胞转移。通过查阅国内外相关文献,本文将对NF-κB信号通路在肝癌侵袭转移过程中的作用研究进展进行综述。
Primary hepatocellular carcinoma is one of common malignant tumours which are seriously threat to human health. China is a large country with liver cancer, and its morbidity and mortality are in the forefront of all kinds of tumours, which seriously damage the national health and aggravate the national economic burden. Due to the strong biological invasiveness of liver cancer cells, liver cancer is very easy to metastasize, which seriously affects the prognosis and quality of life for patients. In recent years, many studies have found that the NF-κB signaling pathway is closely related to the invasion and metastasis of liver cancer. The NF-κB signaling pathway can promote the metastasis of hepatocellular carcinoma cells by promoting tumor angiogenesis and inducing the degradation of extracellular matrix. By referring to relevant literatures domestic and overseas, this paper reviews the research progress of the role of NF-κB siqnalinq pathway in the process of liver cancer invasion and metastasis.
作者
杨子恒
张英
刘海京
刘宙衷
林晓花
YANG Zi-heng;ZHANG Ying;LIU Hai-jing;LIU Zhou-zhong;LIN Xiao-hua(Oncology Department,the Affiliated Hospital of Guangdong Medical University,Zhanjiang 524001,China)
出处
《临床医学研究与实践》
2018年第31期197-198,共2页
Clinical Research and Practice
关键词
NF-ΚB信号通路
原发性肝细胞癌
侵袭
转移
NF-κB signaling pathway
primary hepatocellular carcinoma
invasion
metastasis
