摘要
目的探讨多索茶碱联合异丙托溴铵雾化吸入治疗支气管哮喘急性发作疗效及对肺功能和Th1/Th2型细胞因子的影响。方法选取2014年1月—2017年1月收治的支气管哮喘急性发作106例,按治疗方法分为对照组50例和观察组56例。2组均予以支气管哮喘急性发作期对症治疗,对照组在此基础上予以异丙托溴铵进行雾化吸入治疗,观察组在对照组基础上加用多索茶碱治疗。2组均治疗2周,治疗结束后比较2组肺功能、相关临床症状消失时间、相关细胞因子水平及临床疗效,并记录2组不良反应发生情况。结果观察组咳嗽、喘息改善所需时间及哮鸣音和湿啰音消失时间均短于对照组(P <0. 01)。2组治疗后第1秒用力呼气量(FEV1)、FEV1占预计值的百分比(FEV1/FVC)、晨间测定最大呼气峰值流速(PEFam)和晚间测定最大呼气峰值流速(PEFpm)较治疗前升高,且观察组高于对照组(P <0. 05,P <0. 01)。2组治疗后白介素-2(IL-2)、γ-干扰素(IFN-γ)水平较治疗前升高,且观察组高于对照组(P <0. 05); 2组治疗后IL-5和IL-13水平较治疗前降低,且观察组低于对照组(P <0. 05)。观察组临床总有效率高于对照组,不良反应发生率低于对照组(P <0. 05)。结论多索茶碱联合异丙托溴铵雾化吸入可明显改善急性发作期支气管哮喘临床症状,提高IL-2、IFN-γ水平和降低IL-5和IL-13水平。
Objective To investigate therapeutic effectiveness of Doxofylline combined with Ipratropium Bromide in treatment of acute exacerbation of bronchial asthma and its effects on pulmonary function and Th1/Th2 cytokines. Methods A total of 106 patients with acute exacerbation of bronchial asthma admitted during January 2014 and January 2017 were divided into control group of （u = 50） and observation group （u = 56） according to therapeutic methods. All patients received symptomatic treatment for acute exacerbation of bronchial asthma. On the basis of the treatment, control group was treated with Ipratropium Bromide by atomization and inhalation, while observation group was added with Doxofylline on the basis of the treatment for control group. Patients in two groups were treated for two weeks. After treatment, pulmonary function, disappearance time of relevant clinical symptoms, levels of related cytokines and clinical efficacy were compared, and incidence rates of adverse reactions were recorded in two groups. Results Times of improving cough and gasping, and required times for disappearance of wheezing sound and moist tales in observation group were sig- nificantly shorter than those in control group （P 〈 0.01 ）. After treatment, values of forced expiratory volume in the first second （FEV1）, percentage of FEV1 to forced vital capacity （FEV1/FVC）, morning peak expiratory flow- （PEFam） and evening peak expiratory flow- （PEFpm） were significantly higher than those before treatment in two groups, and the values in observation group were significantly higher than those in control group （P 〈0.05, P 〈0.01 ）. After treatment, levels of interleukin-2 （IL-2） and interferon-γ （IFN-γ） were significantly higher than those before treatment in two groups, and the levels in observation group were significantly higher than those in control group （P 〉 0.05） ; levels of interleukin-5 （IL-5） and interleukin-13 （IL-13） were significantly lower than those before treatment in tw
作者
辛月
XIN Yue(Department of Pharmacy, Integrated Traditional Chinese and Western Medicine Hospital of Wuhan, Wuhan 430000, China)
出处
《解放军医药杂志》
CAS
2018年第10期73-77,共5页
Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
基金
湖北省自然科学基金(2013CFC124)
关键词
哮喘
急性发作
多索茶碱
异丙托溴铵
Asthma
Acute episode
Doxofylline
Ipratropium bromide
