摘要
目的分析广州市2016年人群破伤风抗体水平情况,评价含破伤风类毒素疫苗免疫效果,为改进免疫策略提供依据。方法于2016年在广州市抽取781名健康人群,采集血清标本进行抗破伤风IgG检测,调查人口和疫苗接种信息。结果抗破伤风IgG总阳性率为71.6%(559/781),其中男性(78.1%)比女性(66.1%)高(χ~2=13.638,P<0.00),按时完成免疫(81.6%)比未按时完成(46.4%)高(χ~2=58.295,P<0.00),≤10岁、11～19岁和≥20岁年龄段阳性率呈递减趋势(χ~2=145.594,P<0.00),完成5剂全程免疫后<5年、5～9年和≥10年,阳性率呈下降趋势(χ~2=25.613,P<0.00)。将性别、辖区、年龄段和完成免疫情况纳入Logistic回型模型,11～19岁(OR=3.886,95%CI:1.546～9.766)和≤10岁(OR=16.761,95%CI:6.475～43.385)人群抗破伤风IgG阳性几率比≥20岁人群高,完成免疫人群抗破伤风IgG阳性几率比未完成免疫人群高(OR=1.976,95%CI:1.138～3.431)。结论需进一步加强健康教育,监测免疫效果,建议在成人中引进第6剂含破伤风类毒素疫苗的强化免疫。
Objective To determine seroprevalence ol tetanus antibodies among （,uangzhou people in ZOIO tor improving the immunization strategy against tetanus. Methods Demographic information and immunization records from 781 health Guangzhou people were colleeted for the detection of IgG for tetanus toxin （anti-TT IgG ）. Results The total positive rate of anti-tetanus IgG was 71.6% （559/781） , of which male （78.1%） was higher than female （66.1%） （X2=13.638, P〈0.00） , and the percentage of completion of immunization on time （ 81.6% ） was higher than that of not completed on time （ 46.4% ） （X2--58.295, P〈0.00） ; the positive rate of ~〈10 years old, 11-19 years old and 320 years old showed a decreasing trend （X2=145.594, P〈0.00）. After completing 5 doses of full immunization, the positive rate showed a downward trend at 5 years, 5-9 years and 310 years （X2=25.613, P〈0.00）. Incorporate gender, jurisdiction, age, and completed immunization into the Logistic model, the anti-tetanus IgG-positive rate of the 11~19 years old （0R=3.886, 95%CI： 1.546-9.766） and 10 years old （OR=16.761, 95%CI： 6.475-43.385） population was higher than that of the 320-year-old population. The anti -tetanus IgG-positive rate of the immunized population was higher than that of the un-immune population （OR=1.976, 95% CI： 1.138-3.431）. Conclusion The supplementary immunization with the sixth-dose tetanus toxin-containing vaccine in adults is essential.
作者
张春焕
伍业健
贺晴
ZHANG Chun-huan;WU Ye-jian;HE Qing(Guangzhou Center for Disease Control and Prevention,Guangzhou,Guangdong 510440,China)
出处
《热带医学杂志》
CAS
2018年第9期1242-1245,共4页
Journal of Tropical Medicine
