摘要
目的了解福建省晋江市健康人群破伤风抗体(TAB)状况。方法采用分层随机抽样法,采集晋江市2019年各年龄段健康人群血清,通过酶联免疫吸附试验(ELISA)检测血清TAB水平。使用Excel软件整理数据,运用SPSS 22.0软件进行不同组间TAB阳性率差异比较。结果775份调查样本中,TAB总体阳性率为39.2%(304/775),各年龄组TAB阳性率分别为71.9%(87/121,8~20岁)、53.6%(82/153,21~30岁)、39.3%(57/145,31~40岁)、25.2%(38/151,41~50岁)、16.2%(17/105,51~60岁)和23.0%(23/100,61岁以上);有含破伤风类毒素疫苗(TTCV)免疫史人群TAB阳性率为70.7%(164/232),无免疫史或免疫史不明人群TAB阳性率为25.8%(140/543);TAB阴性者从事破伤风高危行业和低危行业的人群,年龄组分布差异有统计学意义(χ^2=62.185;P<0.000);破伤风高危行业人群中40~50岁年龄组比例为46.79%。结论晋江市健康人群TAB阳性率随年龄增长呈下降趋势,应重视开展TTCV的加强免疫工作。
Objective To determine tetanus antibody(TAB)levels of healthy population in Jinjiang city in 2019.Methods We collected the sera sample of healthy population at different age in 2019 by stratified random sampling,and detected TAB levels by enzyme-linked immunosorbent assay.Results The overall positive rate of TAB among 775 subjects was 39.2%(304/775),and the positive rate of TAB in each age group was 71.9%(87/121,aged 8-20 years),53.6%(82/153,aged 21-30 years),39.3%(57/145,aged 31-40 years),25.2%(38/151,aged 41-50 years),16.2%(17/105,aged 51-60 years),and 23.0%(23/100,over 61 years old),respectively.The positive rate of TAB was 70.7%(164/232)in subjects who had been immunized with tetanus toxoid-containing vaccine(TTCV)in the past years,while 25.8%(140/543)in subjects without or with uncertain TTCV immunization history.For the TAB negative population,there was statistically significant difference in age group distribution between tetanus high-risk industries and tetanus low-risk industries(χ^2=62.185,P<0.000).People aged 41-50 years in tetanus high-risk industries accounted for 46.79%.Conclusion The overall positive rate of TAB in healthy population decreased significantly with age.More attentions should be paid to enhance TTCV immunization.
作者
庄天从
张华捷
李喆
吕新军
王传林
马霄
潘钏愉
Zhuang Tiancong;Zhang Huajie;Li Zhe;Lyu Xinjun;Wang Chuanlin;Ma Xiao;Pan Chuanyu(Jinjiang Luoshan Sub-District Community Health Service Center,Jinjiang 362200,Fujian,China;National Institute for Food and Drug Control,Beijing 102629,China;National Institute for Viral Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 100052,China;National Trauma Center,Emergency Department,Peking University People's Hospital,Beijing 100044,China)
出处
《疾病监测》
CAS
2020年第6期523-526,共4页
Disease Surveillance
基金
国家科技重大专项(No.2018ZX09738–005)。
关键词
破伤风
破伤风抗体
酶联免疫吸附试验
含破伤风类毒素疫苗
免疫
Tetanus
Tetanus antibody
Enzyme-linked immunosorbent assay
Tetanus toxoid-containing vaccine
Immunization
