摘要
[目的]了解潍坊市健康人群百日咳、白喉、破伤风免疫状况,评价无细胞百白破三联疫苗的免疫效果。[方法]2006年对青州、寿光2市采取划片轮转的方式,每个市抽取2个乡镇,每个乡镇抽取3月龄至60岁人群80人,全市共抽取319人,进行百日咳、白喉、破伤风免疫水平检测。[结果]百日咳抗体保护率为68.57%,几何平均滴度(GMT)为1∶326.14,免疫成功率为79.66%;白喉抗体保护率为83.70%,抗毒素含量为0.1326 IU/ml,免疫成功率为90.00%;破伤风抗体保护率为86.52%,抗毒素含量为0.1472 IU/ml,免疫成功率为90.00%;3种抗体保护率均以2~4岁和15~19岁人群较高,20岁以上人群较低,不同年龄组间的差异有统计学意义(P<0.01),不同性别间差异无统计学意义(P>0.05),百日咳抗体保护率和免疫成功率较白喉和破伤风低,2市间的差异有统计学意义(P<0.01)。[结论]3种抗体中百日咳抗体保护率最低为68.57%,抗体水平较低,平均为1∶326.14;20岁以上人群白喉和破伤风抗体保护率较低,为68.18%~75.00%,抗体水平较低,抗毒素平均值分别为0.0398 IU/ml^0.1606 IU/ml。应加强疫苗在保存、运输、接种等各个环节的冷链管理,确保疫苗效价;开展成人白破二联疫苗的接种工作,提高人群免疫水平。
[Objective]To investigate the immune status of DPT in healthy population and evaluate the immune effect. [Methods]80 persons aged from 3 months to 60 years were selected from each town of 2 towns in Qingzhou and Shouguang city,immune level of DTP was tested. [Results]The immune successful rate. protective rate and GMT of pertussis were 79.66% ,68.57% and 1：326.14;the immune successful rate. protective rate and the antitoxin content of diphtheria were 90. 00% ,83.70% and 0. 1326Iu/ml. Those of tetanus were 90.00% ,86.52% and 0. 147 2 IU/ml. The immune successful rates of three antibodies among the groups aged 2-4 years and 15-19 were all higher than the group 〉20, the protective rate of pertussis antibody was higher than those of diphtheria and tetanus. There were statistical differences among the different age groups （ P〈0.01） and between two cities （ P〈0.01）, but there was no statistical difference in different sex （ P〉0.05）. [Conclusion]The result showed that the protective rate of pertussis is the lowest in three kinds of antibody,and the protective rate of diphtheria and tetanus among the age group 〉20 are all lower than those in the other age groups,so in order to ensure the vaccine titer, it is necessary to strengthen the management of cold chain, such as preservation/transportation and inoculation,in the same time to improve the immune level of the population,DT should be inoculated in adult.
出处
《预防医学论坛》
2008年第11期1011-1013,共3页
Preventive Medicine Tribune
关键词
百日咳
白喉
破伤风
抗体
Pertussis
Diphtheria
Tetanus
Antibody
