摘要
目的探究肺癌化疗期间院内感染特点、高危因素和耐药性。方法选取我院收治化疗的200例肺癌合并医院感染患者为研究对象,对患者的临床资料进行分析,并实施病原菌检测和药敏试验,进而对感染特点、感染高危因素以及耐药性进行分析。结果本次研究共收治1980例肺癌患者,其中200例患者出现医院感染,医院感染率为10. 10%。发生感染的部位主要集中在呼吸道、泌尿道、口腔黏膜、胃肠道以及其他部位,其所占比例分别为5. 30%、0. 35%、2. 07%、1. 87%、0. 51%。在本次研究中共分离出病原菌238株,主要病原菌包括革兰阴性菌(80. 67%)、革兰阳性菌(15. 55%)以及真菌(3. 78%)。革兰阴性菌耐药性最高的是环丙沙星,耐药性达到78. 65%;革兰阳性菌耐药性最高为青霉素G,其耐药性为83. 78%;真菌在氟康唑上有着高的耐药性,其耐药性为77. 78%。肺癌患者发生医院感染在患者性别、年龄、临床分期比较上无统计学差异(P> 0. 05),而在中性粒细胞、有无侵入性操作以及有无陪护情况比较存在显著差异(χ2=12. 377、10. 180、23. 560,P <0. 05)。结论在临床上对肺癌医院感染患者的感染特点、高危因素以及耐药性进行分析,进而对高危因素进行有效控制,根据病原菌的耐药性选择合适的抗菌药物,提高临床治疗效果以及预后。
Objective To explore the characteristics of nosoconfial infection, high-risk factors and drug resistance during chemotherapy of lung cancer. Methods The clinical data of 200 patients with lung cancer complicated with nosoeonfial infection who were treated with chemotherapy in our hospital were analyzed. Pathogen detection and drug sensitivity test were carried out to analyze the characteristics of infeetion, high risk factors of infeetion and drug resistance. Results A total of 1980 lung cancer patients were treated in our hospital, 200 of them had nosoeomial infeetion, and the nosoeonfial infeetion rate was 10. 10%. The infection sites were mainly concentrated in the respiratory tract, urinary tract, oral nmeosa, gastrointestinal tract and other parts, which accounted for 5.30%, 0. 35% , 2. 07%, 1.87% and 0. 51%. A total of 238 strains of pathogenic bacteria were isolated in this study. The main pathogens were Gram-negative bacteria （80. 67% ）, Gram-positive bacteria （ 15.55% ） and fungi （3.78%）. The highest resistance of Gram-negative bacteria was eiprofloxaein, and the resistance reached 78.65%. The highest drug resistance of Gram-positive bacteria was penicillin G, and its resistance was 83.78%. Fungi had high resistance to flueonazole, which was 77. 78 %. There was no significant difference in sex, age and clinical stage in patients with lung cancer （ P 〉 0. 05 ） , but in neutrophil, there was significant difference between invasive operation and escort （ χ2 = 12. 377, 10. 180, 23. 560, P 〈 0. 05）. Conclusion The infection characteristics, high risk factors and drug resistance of patients with nosoeonmial infeetion of lung cancer are analyzed in clinic, and then the high risk factors are effectively controlled, and the appropriate antinfierobial agents are selected according to the drug resistance of patho- genic bacteria, in order to improve the clinical efficacy and prognosis.
作者
彭毅
曹坤
田娇娇
PENG Yi;CAO Kun;TIAN Jiao-jiao(Hubei Space Hospital,Xiaogan,Hubei 432000,China)
出处
《临床肺科杂志》
2018年第11期1996-1999,共4页
Journal of Clinical Pulmonary Medicine
关键词
肺癌
化疗
医院感染
高危因素
耐药性
lung cancer
chemotherapy
nosocomial infection
high risk factors
drug resistance
