摘要
目的检测肺癌患者血清淋巴管内皮透明质酸受体1(LYVE-1)水平,并探讨血清LYVE-1用于判断肺癌患者是否发生淋巴结转移及预测患者预后的临床意义。方法采用酶联免疫法(ELISA)检测57例肺癌患者血清中LYVE-1的水平,同时分析血清LYVE-1水平与患者临床病理特征的关系,通过受试者工作曲线(ROC)分析血清LYVE-1用于判断肺癌患者是否发生淋巴结转移的可行性,Kaplan-Meier法进行生存分析,评价LYVE-1用于预测病人预后的临床意义。结果肺癌患者血清LYVE-1为1625.0±343.0 pg/m L;血清LYVE-1与肺癌患者性别、肿瘤组织学分型、血清CEA和CA125无统计学差异(P>0.05),而与TNM分期、淋巴结转移和远处转移情况有关(P<0.05);血清LYVE-1用于诊断肺癌患者发生淋巴结转移的曲线下面积为0.728(95%CI:0.685-0.747,P<0.05);LYVE-1的为1821 pg/m L时,其诊断的敏感性为79%,特异性为68%;血清LYVE-1大于1821pg/m L的肺癌患者预后要比血清LYVE-1小于1821 pg/m L的肺癌患者预后差,两组总生存时间有统计学差异(P=0.035)。结论血清LYVE-1可用于确定肺癌患者是否发生淋巴结转移,并可用于评估病人预后。
Objective To detect the level of serum lymphatic vessel endothelial hyaluronan receptor-1 （ LY-VE-1） in patients with lung cancer, and to investigate the significance of serum LYVE-1 on the metastasis and prog-nosis of lung cancer. Methods The level of serum LYVE-1 in 57 lung cancer patients were detected by Enzymelinked immunosorbent assay （ ELISA） . The clinical and pathologic features with the level of LYVE-1 were analyzed. The specificity and sensitivity of serum LYVE-1 to determine whether lymph node metastasis or not were analyzed by receiver operating characteristic （ ROC） curve. Kaplan-Meier method was used to evaluate overall survival according to cut-off serum LYVE-1. Results The level of serum LYVE-1 was 1625. 0 ± 343. 0 pg/mL, which showed no significant correlation with sexuality, tumor histological type, serum CEA and CA125 （P〉0. 05）, but correlated with high cancer staging, occurrence of lymphnode metastases, and occurrence of distant metastases （P〈0. 05）. Taking 3542 pg/ml of LYVE1 as the cut-off point, the sensitivity was 68% and 79% of specificity, with an area under the curve （AUC） of 0. 728 （P〈0. 05）. Conclusion The serum level of LYVE-1 can be a helpful biomarker to identify lymph node metastases and evaluate the prognosis of patients with lung cancer.
出处
《临床肺科杂志》
2015年第6期1015-1018,共4页
Journal of Clinical Pulmonary Medicine
关键词
淋巴管内皮透明质酸受体1
肺癌
转移
预后
lymphatic vessel endothelial hyaluronan receptor-1
lung cancer
metastasis
prognosis
