摘要
目的探讨血液生化免疫指标与肺癌血行转移的相关性。方法选择68例原发性肺癌患者作为研究对象,根据患者是否出现血行转移将其分为转移组(31例)和未转移组(37例)。对2组患者入组时的血清糖类抗原125(carbohydrate antigen 125,CA125)、骨特异性碱性磷酸酶(serum bone alkalin0e phosphatases,b ALP)、骨钙素N末端中间区域(N-terminal midfragment of osteocalcin,N-MID)以及碱性磷酸酶(alkaline phosphatase,AKP)、乳酸脱氢酶(lactate dehydrogenase,LDH)、神经元特异性烯醇化酶(neuron-specific enolase,NSE)进行检测,并对2组患者随访2年,每个月检测一次上述指标,统计2组患者入组时上述指标并比较。采用spearman相关性分析血行转移患者不同转移数量与上述指标的相关性。结果 2组患者治疗前及治疗后1、3月CA125、OALP、AKP、LDH、NSE、N-MID水平比较,转移组均明显高于未转移组,N-MID水平均低于未转移组(P<0.05),治疗6个月后差异无统计学意义(P>0.05)。spearman相关性分析结果显示,血行转移患者中转移数量与CA125、b ALP、AKP、LDH、NSE水平呈正相关,与N-MID水平呈负相关。转移组患者中位生存时间(5.1±0.4)月,未转移组中位生存时间(9.1±1.1)月,未转移组患者中位生存时间明显高于转移组患者(t=6.015,P<0.05)。结论肺癌患者血液生化免疫相关指标与血行转移具有相关关系,对临床诊断和治疗具有较好的指导意义,对患者预后具有较高的预测价值。
Objective To investigate the relationship between blood biochemical parameters and blood metastasis of lung cancer. Methods 68 patients with primary lung cancer were selected as the research object,and the patients were divided into 2 groups according to whether the patients had hematogenous metastasis group（ n = 31 ） and non metastasis group （ n = 37）. The a- bove indexes were compared between the 2 groups. The serum carbohydrate antigen 125 （ CA125 ） , bone specific alkaline phos- phatase （serum bone alkalin0e phosphatases, bALP） , N-terminal midfragment of N at the end of osteoealein（N-MID） and alkaline phosphatase（ AKP）,lactate dehydrogenase （LDH）, neuron specific enolase （ NSE ） of the 2 groups were detected, and reviewed once a month. The 2 groups of patients were followed up for 2 years. Spearman correlation analysis was used to analyze the correla- tion between the number of patients with hematogenous metastasis and the above indexes. Results Before and after treatment for 1 months and 3 months, CA125, OALP, AKP, LDH, NSE, of metastasis group were significantly higher than the control group, N- MID were lower than the control group （ P 〈 0.05 ）, the differenee was not statistically significant after 6 months of treatment （ P 〉 0.05 ）. Spearman correlation analysis showed that the number of patients with hematogenous metastasis was positively correlated with CA125, bALP, AKP, LDH, NSE, and negatively correlated with N-MID. The median survival time of the patients in the meta- static group （5.1 ± 0.4） months,the median survival time of the non metastatic group （9.1 ± 1.1 ） months,the median survival time of the patients without metastasis was significantly higher than that of the control group （t =6.015 ,P 〈 0.05 ）. Conclusion There is a correlation between blood biochemical parameters and hematogenous metastasis in patients with lung cancer,which has a good guiding significance for clinical diagnosis and treatment, and has a high predictive valu
出处
《实用癌症杂志》
2018年第1期46-49,共4页
The Practical Journal of Cancer
关键词
血液生化免疫指标
肺癌
血行转移
相关性
Blood biochemical immune index
Lung cancer
Hematogenous metastasis
Correlation
