摘要
目的：探讨血清白蛋白对食管癌放疗患者生存时间的影响，为食管癌患者的放疗敏感性提供判断依据。方法收集接受放射治疗的食管癌患者365例，对其进行随访观察，采用Kaplan-Meier法及Log-rank检验进行生存分析，并以Cox回归进行多因素分析。结果男性、TNM Ⅲ~Ⅳ期、淋巴结转移、放疗并发症、血清白蛋白≤40 g/L是食管癌放疗患者生存时间的独立危险因素[HR（95％CI）分别为1.539（1.121~2.114），1.734（1.125~2.674），1.763（1.308~2.376），1.642（1.220~2.211），2.162（1.616~2.893）]。结论血清白蛋白水平可以预测食管癌放疗癌患者的生存时间，血清白蛋白水平≤40 g/L者的生存时间明显短于﹥40 g/L者。性别、TNM分期、淋巴结转移、放疗并发症是影响食管癌放疗患者生存时间的独立危险因素。
Objective To explore the effect of serum albumin on the survival time of esophageal cancer patients treated by radiotherapy,and to provide reference for sensitivity assesment of esophageal cancer patients treated by radiotherapy. Methods Data of 365 esophageal cancer patients treated with radiotherapy were collected. The patients were followed up. The survival analysis was performed by Kap-lan-Meier method and Log-rank test,and Cox regression was used for multivariate analysis. Results Sex （ male）,TNM stage Ⅲ -Ⅳ,lymph node metastasis,radiotherapy complications,albumin≤40 g/L were independent risk factors for survival time of patients with esophageal cancer after radiotherapy[ HR （95%CI）were 1. 539（1. 121 -2. 114）,1. 734（1. 125 -2. 674）,1. 763（1. 308 -2. 376）,1. 642 （1. 220-2. 211）,and 2. 162（1. 616-2. 893）respectively]. Conclusions The serum albumin level can predict the survival time of patients with esophageal cancer undergone radiotherapy,and survival time of the patients with albumin level below 40 g/L was significantly lower than whose the albumin level a-bove 40 g/L. Sex,TNM stage,lymph node metastasis and radiotherapy complications were independent risk factors for survival time in patients with esophageal cancer.
出处
《中国实用医刊》
2016年第16期17-19,共3页
Chinese Journal of Practical Medicine
基金
河南省科技厅重点科技攻关项目（142102310502）
关键词
血清白蛋白
食管癌
放疗
生存时间
Serum albumin
Esophageal cancer
Radiotherapy
Survival time
